Enhancer

2,3-Dimercapto-1-propanesulfonic acid (DMPS)
Unithiol, Dimovol, DMPS-Hey, Dimaval

Chelating Agent

Revised 2018-03


      Top INDEX
    • Basics: Enhancement.
    • About: Wikipedia.
    • About: DMPS, nd Health Facts.
    • Details: DMPS Adverse Experiences.
    • Details: DMPS chelation therapy.
    • Caution: Common & Rare Side Effects.

    • Protocol: An example.
    • Amanda: Mercury: Chelating with DMPS.
    • Protocol: Mercury Detoxification, Mercola.
    • Technical: The Andy Cutler Protocol.

      Product Possibilities, NOT Recommendations.
    • Article : Use of liposome encapsulated DMPS ....
    • Product: DMPS, Living Supplements, SA

    • Insight: Avoid combining DMPS and supplements.
    • Insight: Backfire outcomes from lack of professionalism.
    • Insight: Chorella intolerance is not uncommon.
    • Insight: Food intake relevancy is mandatory for Benefits.
    • Insight: Frequency of Use determines Benefit or setback.
    • Insight: Ignorance & misinformation abound in health care.
    • Insight: Legal Considerations; Government regulations.
    • Insight: Minerals -- Getting Healthy, or, Toxic?

    • -LINKS: from Lenntech, and others.
    • -Focus-: Monographs on Toxins and Enhancers.

Enhancement is a Potential, not a Guarantee.
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Too much of either leads to death; air = embolism; water = drowning.
Too little of either leads to death; air = suffocation; water = dehydration.
The healthy Balance for each of us is dynamic and personal.



Basics: Enhancement. INDEX
https://en.wikipedia.org/wiki/2,3-Dimercapto-1-propanesulfonic_acid
LINK 2:

A study was undertaken of DMPS use by workers involved in the production of a calomel skin bleaching lotion and in direct contact with mercurous chloride and that already showed elevated urine mercury levels.

The sodium salt of DMPS was found to be effective in lowering the body burden of mercury and in decreasing the urinary mercury concentration to normal levels.



About: DMPS, INDEX
https://en.wikipedia.org/wiki/2,3-Dimercapto-1-propanesulfonic_acid
LINK 2: http://rmalab.com/sites/default/files/tests/instructions/20140107_CI_UrineElement.pdf
LINK 3: http://www.klinghardtacademy.com/Articles-with-Protocols/DMPS-Challenge.html

2,3-Dimercapto-1-propanesulfonic acid (abbreviated DMPS) and its sodium salt (known as Unithiol) are chelating agents that form complexes with various heavy metals.
They are related to dimercaprol, which is another chelating agent.

The synthesis of DMPS was first reported in 1956 by V. E. Petrunkin.
The effects of DMPS on heavy metal poisoning, including with polonium-210, were investigated in the following years. DMPS was found to have some protective effect, prolonging the survival time.

Pharmaceutical chelating agents like DMPS, DMSA and EDTA do not actually ‘burrow’ into cells and remove toxic elements. In fact, chelating agents extract toxic and essential elements from the interstitial fluid around cells in tissue and bring them into systemic circulation. Once in circulation, the toxic (and essential) elements are available for excretion in urine.

DMPS (Sodium 2,3-dimercaptopropane-l-sulfonate) is a sulfonic acid salt with free SH-groups that forms complexes with heavy metals such as mercury, cadmium, arsenic, lead, copper, silver, tin, and others. This agent was first developed in China, was then introduced in Russia (used for workers injured by exposure to heavy metals) , and went from there to West Germany.

Professor Max Daunderer, M.D., in Munich published a number of papers on the use of DMPS.
He found that DMPS is the ideal agent to detox patients who have suffered from amalgam toxicity after the fillings have been removed. Intravenous DMPS leads to dumping of large amounts of heavy metals through the kidneys. 50% are excreted during the six hours following the shot, 90% after 24 hours.

Oral DMPS leads to excretion of heavy metals mostly via the stool, but has been in our experience much less effective.

DMPS has ... (an) agent to "clean" the kidneys of heavy metal residues and improve kidney function in patients who have been exposed to heavy metals.

DMPS is available in 250 mg/5 cc ampules from
ApotheCure,
contact Gary Osborn, R.Ph., C.C.N., at
1-800-969-6601.

The 24-hour urine heavy metal analysis is performed through
Dr's Data in Chicago (telephone #: 1-800-323-2784).



About: DMPS, Health Facts. INDEX
https://en.wikipedia.org/wiki/2,3-Dimercapto-1-propanesulfonic_acid
LINK 2: http://rmalab.com/sites/default/files/tests/instructions/20140107_CI_UrineElement.pdf

Murran P.
Mercury elimination with oral DMPS, DMSA, vitamin C and glutathione: an observational clinical review.
Alt Ther. 2006;12(3):70-75

LINK 3: http://www.klinghardtacademy.com/Articles-with-Protocols/DMPS-Challenge.html

A study was undertaken of DMPS use by workers involved in the production of a calomel skin bleaching lotion and in direct contact with mercurous chloride and that already showed elevated urine mercury levels. The sodium salt of DMPS was found to be effective in lowering the body burden of mercury and in decreasing the urinary mercury concentration to normal levels.

DMPS administrated to a mercury poisoned animal model failed to remove the mercury from tissues and reduce the inorganic mercury burden in the brain. A 2008 study reported a case of Stevens–Johnson syndrome (SJS), a potentially serious disease, in a child undergoing chelation therapy with DMPS; the SJS resolved gradually after the chelation therapy was stopped

DMPS (2,3-dimercapto-1-propanesulfonic acid) is a synthetic amino acid chelating agent.
DMPS forms a water soluble complex with toxic elements and is believed to eliminate heavy metals through the kidneys, liver, and gastrointestinal tract. DMPS accelerates excretion of inorganic and organic mercury, arsenic, bismuth and lead. Mobilization of toxic elements after DMPS treatment may aggravate symptoms related to toxic elements.

Intravenous DMPS should not be used in patients who still have silver amalgam fillings.
DMPS seems to appear in the saliva and dissolves the surfaces of the existing amalgam fillings.
This process occurs over a series of several days. However, the blood concentration of DMPS lessens very quickly.
Therefore, the patient with amalgam fillings can become acutely toxic from heavy metal injury to the mucosa of the gut following a DMPS shot. The DMPS should be given however immediately after the last amalgam filling in the patient's mouth has been removed.

Through the use of neural kinesiology testing, we have found that the kidneys, the liver, and the brain typically get stressed quite a bit approximately one week after the DMPS shot when "new" heavy metal is moving from intracellular to extracellular. Therefore, the mercury that comes out after the first DMPS shot represents only recent exposure, further injections will eventually get the slow body pools.

The cells start "joyfully" dumping the heavy metal content into the connective tissue.
However, if DMPS is not given again within a reasonable period of time, the heavy metals are redistributed again back from extracellular to intracellular. Extracellular heavy metals cause symptoms such as pain, burning, gut problems, and most other known heavy metal related symptoms. If they are intracellular, the patient appears to be asymptomatic, but his immune system is misfunctioning on a deep level leading to more serious disease later on.

When the heavy metal analysis comes back negative, one can often still find "nests" of heavy metal toxicity in various tissues using neural kinesiology. The patient will then benefit from further injection of DMPS locally using the neural therapy approach (segmental injections, paravertebral injections, autonomic ganglion blocks with lidocaine and a small amount of DMPS -10 parts lidocaine, 1 part DMPS).

If the DMPS is given often enough, the clinical improvements of patients are dramatic and often miraculous.
If DMPS is given too few times, the patient will sometimes not experience any lasting clinical improvement (since the heavy metal burden of the body is not yet sufficiently decreased).

The most consistent observation that we have made is that each patient treated several times with DMPS seems to become biologically younger (hair grows back, skin looks more supple and rosy, lab parameters shift back to normal). Chronic pain and neurological disease appear to be the most gratifying indications.

Even though DMPS does not cross the blood brain barrier, major improvements in neurological disease are often seen. This is easily explained through the laws of osmosis: If the connective tissue and vascular system is free of heavy metals and the brain and nervous system has a high heavy metal burden, given enough time, the heavy metals will shift from the brain into the other tissues where the body can excrete them.

... we like to finish the treatment (when no more heavy metals are detected through the urine challenge test) with a three day regimen of DMSA. The patient is given 250 mg capsules of DMSA: Take two capsules three times a day for three days in a row. Patients can experience severe side effects with DMSA-due to the tremendous shift of minerals within the nervous system caused by this agent. We have found that moderate amounts of alcohol such as wine or beer counteract some of these side effects.

We also recommend that each patient undergoing the DMPS treatment is on the Williams/Klinghart detox program (Chlorella, antioxidants, etc.). Recently, we have found that moderate doses of odorless garlic appear to tremendously help the excretion of heavy metals while the patient is undergoing this intense detox program. Saunas, exercise, and colonics are also helpful.

Even though DMPS has a high affinity for mercury, the highest affinity appears to be for copper and zinc, which are the metals that appear first in high levels in the urine. The "normal" urine challenge test will show high copper levels and low manganese levels. I consider'someone only copper toxic if his/her level is more than fourfold the upper limit of the reference range. If the patient has a high body burden of these metals, no mercury comes out with the first test. Only subsequent DMPS tests will show the mercury.

As long as there is a high body burden of mercury, virtually none of the other heavy metals are coming out.
Only as the mercury level starts to drop, does the lead, nickel, silver, cadmium, and so on appear in the urine. This is important to understand: as different heavy metals appear in the urine test at different times, so do the patient's symptoms change while going through the detox. The ideal book that describes the symptoms caused by toxicity from any of the particular heavy metals are the old standard texts in homeopathy such as "The Materia Medica with Repertory" from Boericke. One can read up the particular "symptom picture" of nickel toxicity, silver toxicity, copper toxicity, etc.

Currently (2017?) in the U.S.A., the University of Arizona is conducting experiments using DMPS20.



Details: DMPS Adverse Experiences. INDEX
http://www.dmpsbackfire.com/default.shtml

Patient Reports:
LINK 2: http://www.dmpsbackfire.com/reports/default.shtml

    Possible side effects include
    • pain,
    • burning,
    • gut problems,
    • shivering ,
    • fever or skin reactions,
    • itching and exanthema or rash may occur,
    • erythema exsudativa multiforme,
    • Stevens-Johnson syndrome,
    • nausea ,
    • dizziness ,
    • weakness,
    • pancreatitis,
    • headache,

    • muscle pain or weakness,
    • diarrhea,
    • stomach pain,
    • rashes,
    • sensomotor neuropathy,
    • decreased urination,
    • cardiac arrhythmias,
    • conjunctivitis,
    • blepharal spasm,
    • tingling of the hands,
    • a burning sensation in the penis,
    • salivation,
    • sweating of the forehead, hands and other areas.

Intravenous DMPS should not be used in patients who still have silver amalgam fillings.
DMPS seems to appear in the saliva and dissolves the surfaces of the existing amalgam fillings.
This process occurs over a series of several days. However, the blood concentration of DMPS lessens very quickly. Therefore, the patient with amalgam fillings can become acutely toxic from heavy metal injury to the mucosa of the gut following a DMPS shot. The DMPS should be given however immediately after the last amalgam filling in the patient's mouth has been removed.

Through the use of neural kinesiology testing, we have found that the kidneys, the liver, and the brain typically get stressed quite a bit approximately one week after the DMPS shot when "new" heavy metal is moving from intracellular to extracellular. Therefore, the mercury that comes out after the first DMPS shot represents only recent exposure, further injections will eventually get the slow body pools.

The cells start "joyfully" dumping the heavy metal content into the connective tissue.
However, if DMPS is not given again within a reasonable period of time, the heavy metals are redistributed again back from extracellular to intracellular.

Extracellular heavy metals cause symptoms such as pain, burning, gut problems, and most other known heavy metal related symptoms. If they are intracellular, the patient appears to be asymptomatic, but his immune system is misfunctioning on a deep level leading to more serious disease later on.

When the heavy metal analysis comes back negative, one can often still find "nests" of heavy metal toxicity in various tissues using neural kinesiology. The patient will then benefit from further injection of DMPS locally using the neural therapy approach (segmental injections, paravertebral injections, autonomic ganglion blocks with lidocaine and a small amount of DMPS -10 parts lidocaine, 1 part DMPS).

... The purpose of this website (http://www.dmpsbackfire.com/) is to share information regarding DMPS, and to collect information from those who have experienced adverse effects from this drug. In the process I hope not only to inform those individuals who are considering the use of this drug, but to stimulate the appropriate research to determine safe protocols for its use. It is my hope that researchers will want to investigate this collection of patient reports.

My name is Jana. I am not a doctor or scientist.
I am a patient whose life was derailed by a single injection of DMPS.
Since then, I have tried to learn everything I can about this drug and its effects on the physiology of the human body.
There is surprisingly little reliable information available on this subject.

What I have learned is that DMPS is not approved by the FDA. It is considered an experimental drug.
I have found no evidence of the existence of appropriate clinical trials by which practitioners can be guided in its safe use.

The discovery that was most disturbing to me was that some physicians and others were misleading (either through ignorance or contrivance) patients about the safety and efficacy of this drug. I am alarmed at the proliferation of health care providers who are enrolling patients in what amounts to experimental medicine without obtaining their informed consent. Unless patients know that there are potentially serious side effects to this drug, no informed consent can be given, and the patient becomes nothing more than a lab rat.

You can find assertions on the internet and elsewhere that DMPS is safe. I take issue with those claims.

Last Updated: August 17, 2011


INDEX

II. SAFETY

  • A: Introduction
  • B: DETOX OR RETOX?
  • C: Dr. Thomas Levy
  • D: Informed Consent
  • E: Risk Factors
    • 1: AMALGAMS
    • 2: ALLERGY TO SULFA DRUGS OR SULFITES
    • 3: ELEVATED CADMIUM, IRON OR SELENIUM LEVELS
    • 4: ELEVATED COPPER LEVELS



A. Introduction XD-INDEX

I've spoken to physicians, patients, researchers, biochemists, toxicologists and others about this drug.
The picture I get is that the majority of patients who try DMPS will not have a serious adverse reaction. (Nor will this majority experience any significant improvement in their conditions as a result of using DMPS.) Most patients will have only mild side effects.

A minority of patients will experience some benefit.
(My researchers say that this benefit would also have occurred by using oral DMSA.)
Another minority of patients will experience a serious adverse reaction. (I consider a "serious adverse reaction" to be a disabling reaction which lasts for weeks, months or more.)

Because neither physicians nor patients are reporting these adverse reactions, it is impossible to know just how high this percentage is. As stated elsewhere, estimates by those who have taken an interest in this drug indicate that the incidence of serious adverse reactions is anywhere from 5% (a victim/researcher) to 20% (a physician and a pharmacist). But no one really knows. I have reason to suspect, from the reports of Ray and "M" that the most serious adverse effects are not being reported by those who claim to have done clinical trials.

The term "backfire" means "to have the reverse of the desired or expected effect".
DMPS is used to remove heavy metals from the body. However, sometimes DMPS can have the reverse effect.
It can actually induce metal poisoning.

I believe that the fact that many patients will not experience serious adverse reactions, is due more to luck than the skill or knowledge of most practitioners. There is still too much left to be learned about this drug for there to be truly knowledgeable practitioners. To the best of my knowledge, there have been no honest clinical studies which address safety issues, and which will guide practitioners in distinguishing patients who will fare well from those who will suffer serious side effects. Without this knowledge, taking DMPS is the equivalent of playing Russian roulette.

To convince you that DMPS is safe, some practitioners may tell you "It has been used safely in Europe for years." I don't believe it. I've now communicated with enough people in Canada and Europe (as well as the United States) to know better. It HAS been used in Europe for years, and there are many patients there who have suffered very serious side effects.

Most physicians learn about DMPS at seminars where anecdotal evidence is provided, and then they run back to their offices and start "practicing" on patients. Some patients will experience no serious side effects. The first backfire comes as a surprise. I've talked to physicians who have stopped using DMPS precisely because they have no way of foretelling who will have a serious adverse reaction. Other doctors cause a backfire, and keep on shooting. One physician told me quite nonchalantly that a female patient collapsed in his office after an injection of DMPS. She had to be taken out on a stretcher.

Another DMPS advocate cavalierly dismisses reports of serious adverse reactions by saying that proper protocols were not followed. Of course, the "protocols" are very complex, and in a constant state of flux. It is a convenient, if disingenuous, way to rationalize these adverse reactions.

Watch for these self-serving platitudes:

"you're a sensitive patient"; "mercury detox is more of an art than a science"; "you have to feel worse to feel better"; "in Europe, patients feel they haven't gotten their money's worth if they don't leave the doctor's office feeling worse"; "when you're on the cutting edge, there are bumps in the road, you're a bump in the road".
All of these are insulting to the patient, and the hallmark of a clinician who doesn't know what he's doing. Run. (top)



B. DETOX OR RETOX? XD-INDEX

There are various theories about why DMPS can be devastating to some people.
One I find compelling is that DMPS frees up stored mercury, but is unable to maintain its bond to all that it has shaken loose. That permits the now loose mercury to enter the bloodstream and be redistributed to other places in the body, doing new damage. Remember that these chelators merely mobilize mercury. It takes properly functioning excretory systems to remove the now DMPS-bound metals from the body.

Galen Knight, Ph.D., is a chemist knowledgeable about metal poisoning. This is what he told me:

"Much of my time is besieged by people who have tried systemic chelators as a way of detoxing, finding out only too late that edta, DMPS or DMSA draws the metal toxins out of the cells and bones (where the body sequesters them as conjugates with glutathione, metallothionine and phosphates, respectively) and then dumps them into the bloodstream where they poison the immune and nervous systems, and vital organs. Consequently these poor individuals can remain extremely toxic and incapacitated for years after their `detoxing', or perhaps one should say `retoxing'.



C. Dr. Thomas Levy XD-INDEX

Since launching this website I have received a number of messages from physicians.
Each of them thanked me for providing information which was new to them, or for publicizing what they knew to be true.

Dr. Thomas Levy is a cardiologist who co-authored
Uninformed Consent with Hal Huggins.
In the book, Drs. Levy and Huggins discourage the use of synthetic chelators in general, and DMPS in particular.
At page 252 they state:

"Heavy metal chelators almost always overaccelerate the detoxification of the post-TDR (total dental revision) patient. DMSA, DMPS, and EDTA can all do this. DMPS is consistently the greatest offender here. Immune declines and clinical illness can result for weeks and sometimes even months after only one injection of DMPS".

Dr. Levy has given me permission to repeat what he has told me directly. In his words,

"DMPS is an unqualified sledge hammer to the immune system".

He referred to the administration of DMPS as an "assault".
Dr. Levy believes that synthetic chelators should just plain be avoided most of the time.
Most patients simply don't need them.

However, on those occasions where it is TRULY necessary for the patient, Dr. Levy states that contemporaneous administration of intravenous vitamin C can reduce the clinical toxicity.

I have great respect for Dr. Levy, so I told him about how the intravenous vitamin C induced a nasty bout of kidney stones for me.

(I have no known risk factors for stone formation.)
Dr. Levy found my experience to be unusual, and suggested I try to determine what else my physician may have included in the IV. So far, I have been unable to do so. However, my urologist routinely advises his kidney stone patients to reduce or eliminate vitamin C intake. Unfortunately, there are no scientific studies regarding the administration of vitamin C contemporaneously with DMPS. Such studies would be welcome.

I've heard of a relatively new protocol which calls for the administration of glutathione along with the intravenous vitamin C. That's an intriguing notion to me, and I believe that it deserves further study.

However, let me reiterate. Synthetic chelators are powerful drugs with potentially serious side effects.
I have found no consensus among experts that serious adverse reactions can be avoided under any of the currently used protocols. Honest clinical trials are desperately needed. (top)



D. Informed Consent. XD-INDEX

What concerns me most is that patients are being told that DMPS is a harmless drug. It is not.
There are very serious risks involved.

A group which advocates the use of parenteral DMPS makes the following statements on their website:

"Side effects of the medication are minimal. In some people, mild reactions have been noted. The symptoms include nausea, itching, elevated body temperature and fever. These symptoms are rare and believed to be attributed to the actual detoxification process."
I find those claims to be both misleading and irresponsible, given the patient reports I have received.

I was not told that DMPS is an experimental drug.
I was not told that there could be very serious side effects.
Instead, my physician led me to believe that the drug was "harmless".
I was not given the opportunity to give an informed consent, because I wasn't informed of anything.

As I learned more about the physicians, dentists and clinics using DMPS, I couldn't find a single incident where patients were being properly informed. These patients could not make an educated decision about their treatment, because the practitioners were not being forthright. I encourage all patients to conduct their own investigations (for themselves and their loved ones) before beginning a mercury detoxification program, especially one involving synthetic chelators. (top)



E. Risk Factors XD-INDEX

While there is much to be learned about this drug, we do have some knowledge which should be employed before using DMPS on any patient. I have accumulated this information from a variety of sources, and hope it will help guide patients and physicians.

When you buy a bottle of Advil, you will receive a lengthy insert describing its indications and side effects.
When you obtain a prescription for an approved drug from your doctor, your pharmacist will provide you with a patient insert, informing you of all of the relevant information you need to know to use the drug safely. No doctor or pharmacist I have spoken to has that kind of information, and my guess is that it doesn't exist for DMPS.

The closest I've come to an informative patient document is a paragraph in the scientific monograph on DMPS from Heyltex. ("DMPS-Heyl" refers to the parenteral form of DMPS; "Dimaval" refers to the oral form.) The relevant paragraph reads as follows (the emphasis is mine):

"Contraindications:
DMPS should not be used in the presence of hypersensitivity to DMPS or its salts.
Especial care is required on injection of DMPS-Heyl in patients with allergic asthma symptoms.
Side effects: Occasionally shivering, fever or skin reactions, presumably of an allergic nature, such as itching and exanthema or rash may occur, which are generally reversible on withdrawing treatment. In isolated cases severe allergic skin reactions (e.g. erythema exsudativa multiforme, Stevens-Johnson syndrome) have been reported.

Long term use of DMPS can influence the mineral balance, especially for elements zinc and copper.
Administration of DMPS causes mobilization of mercury taken up in the body.
In isolated cases therefore, CLINICAL SYMPTOMS OF MERCURY POISONING MAY BE PRODUCED.
In individual cases there may be raised levels of certain enzymes (transaminases).

After ingestion of Dimaval (DMPS) nausea may rarely occur.
Cardiovascular reactions may occur, especially on too rapid injection of DMPS-Heyl and is apparent as a fall in blood pressure, nausea, dizziness and weakness generally a short time after injection."

(Note that Heyltex acknowledges that "clinical symptoms of mercury poisoning may be produced."
In other words, DMPS can INDUCE mercury poisoning! Trust me, you don't want to experience this. Mercury poisoning affects you physically, mentally and psychologically. In has driven victims insane - thus its reference as "Mad Hatter's disease".)

A reader sent me the Informed Consent form which was to be used in a proposed clinical trial of DMPS. (I was told by a physician who was to participate in this trial that it never got off the ground) The Informed Consent form lists the following adverse effects:

Pancreatitis (inflammation of the pancreas), nausea, headache, muscle pain or weakness, gastrointestinal symptoms (nausea, diarrhea, stomach pain), rashes, sensomotor neuropathy, decreased urination, cardiac arrhythmias and allergic reactions.

The following additional risk factors have been identified for me by researchers and practitioners.



1. AMALGAMS XD-INDEX

I believe that there is now (2011) almost universal agreement that DMPS should not be given to any patient who has metal in his/her mouth. It seems the drug can quickly enter the saliva, and begin to dissolve the metals in the mouth, pulling them into the body, and resulting in "acute poisoning of the mucosa of the gut". More researchers are recommending that synthetic chelators be avoided for six months to a year after amalgam replacement. (Amalgam replacement will cause an elevation in mercury levels in the body for a period of time afterwards. It only makes sense to avoid increasing the blood burden of metal during this time.)



2. ALLERGY TO SULFA DRUGS OR SULFITES XD-INDEX

One researcher told me that a patient is more likely to have an adverse reaction to DMPS if s/he is allergic to sulfa drugs, or sulfites. I couldn't ever drink wine, and wine has sulfites. So perhaps my adverse reaction had something to do with this.



3. ELEVATED CADMIUM, IRON OR SELENIUM LEVELS. XD-INDEX

Because DMPS is not an approved drug, you can't find it in the Physician's Desk Reference.
You can, however, find its predecessor, Dimercaprol. (I believe it is also known as BAL or Unithiol.)
Because of its similarities to DMPS, the cautions for its use should probably be observed when using DMPS.

The PDR states that Dimercaprol is indicated for poisoning by arsenic, lead gold and mercury. It further indicates that it is appropriately used for ACUTE mercury poisoning, but not for chronic mercury poisoning. It is contraindicated in patients with high levels of selenium, iron, or cadmium because the resulting complexes are more toxic than the metal itself, especially to the kidneys. Other adverse reactions listed are:

a rise in blood pressure accompanied by tachycardia; nausea and sometimes vomiting; headache; burning sensation of the lips, mouth and throat; a feeling of constriction, even pain, in the throat, chest or hands; conjunctivitis; lacrimation; blepharal spasm; rhinorrhea; salivation; tingling of the hands; a burning sensation in the penis; sweating of the forehead, hands and other areas; abdominal pain; and occasional appearance of painful sterile abscesses.

It further stated that these symptoms may be accompanied by a feeling of anxiety, weakness, and unrest, which could be relieved by administration of an antihistamine.



4. ELEVATED COPPER LEVELS XD-INDEX

A medline search has revealed a study which demonstrated that DMPS can combine with copper to form more toxic complexes. I had elevated copper levels (from copper pipes in my house) prior to my injection with DMPS, so it's possible I suffered from acute copper poisoning as a result. See:

Aaseth, J, Ribarov,S, Bacher,P;
"The Interaction of copper (Cu++) with the erythrocyte membrane and 2,3-dimercaptopropane-sulfonate in vitro:
a source of activated oxygen species."
Pharmacol Toxicol 1987 Oct.; 61(4): 250-3. (top)



Detail: DMPS chelation therapy. INDEX
http://www.chamberlins.com/ns/DisplayMonograph.asp?
StoreID=A59A6B1C10E44C9E9420A7A75B27460A&DocID=bottomline-ungraded-dmpschelation 

Akin's Natural Foods Market
7807 East 51st Street
Tulsa, OK 74145
(918) 663-4137

    Technique

    • Chelation agents like 2,3-dimercaptopropane-1-sulfonate (DMPS) and meso 2,3-dimercaptosuccinic acid (DMSA) are available over the counter in some countries. The form of DMPS taken by mouth, Dimaval® (not sold in the United States), is available in 100-milligram capsules.

    • Some researchers suggest that a combination of antioxidants, herbal extracts, and chelators may be a promising area of future study for heavy metal intoxication.

    • In general, chelation sessions last about three hours and may be scheduled 1-3 times weekly. Secondary sources suggest that 20-30 sessions may be recommended.

    • However, there is no standard administration protocol for DMPS.
      The decision is left up to the discretion of the healthcare provider. ...

    Background

    • During chelation therapy, chemical compounds and proteins are injected into the blood to treat conditions such as lead toxicity.

    • Chelation therapy with 2,3-dimercaptopropane-1-sulfonate (DMPS) has been used to treat acute and chronic heavy metal poisoning. It is thought to work by forming an insoluble complex with the metal that is firmly bound to intracellular sites.

    • Heavy metals such as arsenic, lead, cadmium, and mercury may induce toxic effects in humans due to an imbalance between pro-oxidant and antioxidant homeostasis, termed oxidative stress. Long-term exposure to heavy metals affects normal cellular defense mechanisms and eventually causes apoptosis (cell death). Heavy metals, such as lead and arsenic, interfere with the normal functioning of the central nervous system, hematopoietic system, liver, and kidneys.

    • Although scientific evidence for effective heavy metal toxicity treatment is not adequate, chelation therapy with chelating agents, such as DMPS and ethylene diamine tetra-acetic acid (EDTA), is considered the best-known treatment for metal poisoning or toxicity.

    • Both oral and parenteral forms of the substance are available in Europe, but DMPS is only approved in the United States as a bulk chemical. It must be compounded by a pharmacist at the request of the prescribing physician and given as a slow intravenous push. EDTA is another substance used for chelation therapy. EDTA has been approved by the U.S. Food and Drug Administration (FDA) for treating lead poisoning and poisoning from other heavy metals. ...



Caution: Common & Rare Side Effects. INDEX
https://www.evenbetterhealth.com/heavy-metal-poisoning-treatment.php
LINK 2: http://www.ndhealthfacts.org/wiki/DMPS

DMPS can also be taken orally, intravenously, or as a suppository, though it is most commonly given as an infusion or injection. It is an experimental drug, and has NOT been approved by the FDA. Its primary usefulness is for severe metal poisoning when all other detoxification methods have been exhausted.

There have been reports of serious and devastating side effects with DMPS, since it works quite rapidly at excreting the toxic metals from the organs into the bloodstream and from the bloodstream into the kidneys.

Some scientists believe that the severe side effects experienced by some people are the result of too much mercury or other metals being dumped into the bloodstream at once, which overwhelms the organs of excretion, namely the liver and kidneys. Instead of being properly excreted, these toxic metals are redistributed and reabsorbed by the vital organs, where they poison the immune system and central nervous system.

Side effects in people who have generally tolerated DMPS include dizziness and weakness, the lowering of blood pressure, and flu-like symptoms.

It is NOT RECOMMENDED for people who still have their amalgam fillings, as DMPS can quickly enter the saliva and begin to dissolve the metals in the mouth, resulting in acute poisoning.

Infrequent side effects of DMPS:

  • dizziness, Less Severe
  • weakness,, Less Severe
  • the lowering of blood pressure, Less Severe
  • flu-like symptoms, Less Severe

    A Caveat for all Chemical Chelator Usage.

    hese most commonly known chelators need to be taken in fairly high doses to be truly effective.
    Because of this, side effects are virtually unavoidable. Accordingly, these potent pharmaceuticals cannot be taken for an extended period of time (Goodman & Gilman).

    As well, because of the high doses needed with these chelators, essential minerals are almost always chelated out of the body as well. Minerals most commonly lost include zinc, magnesium, manganese, molybdenum, and selenium, which then need to be replaced.

    Toxic metals are often stored in the brain, and none of the above-mentioned chelators cross the blood/brain barrier.

    And last but not least, there has been concern that the metals loosened by the chelating agents are not always properly excreted. Instead, they may be reabsorbed in different parts of the body, causing more damage to the immune system and vital organs. This is why some individuals can remain just as sick after chelation as before, sometimes for years after their "detoxing".



    Protocol: An example. INDEX
    http://www.klinghardtacademy.com/Articles-with-Protocols/DMPS-Challenge.html

    Our protocol is similar to the one developed by German toxicologist, Max Daunderer, M.D.2,19.

    On the day of the last amalgam removal, the first treatment is given.
    In patients who had the amalgam taken out months, years, or decades before, this diagnostic test and treatment method should still be used as soon as the problem of heavy metal toxicity is suspected.

    1. The content of the ampule (or 3 mg/kg body weight) is drawn up into a 5 cc syringe and slowly injected into the patient with a 25 gauge butterfly over a 5 minute period of time (1 cc per minute).

    2. The patient is then asked to collect all urine for 24 hours in the container provided by Dr's Data.

    3. On the lab slip, the doctor has to mark off the following urine tests: "special mercury" and "elements".

    4. The patient will fill the provided mailing tube with a sample from the urine collected over the 24-hour period.

    5. After voiding the first urine into the container, the provided ampule of nitric acid is added to the urine in the container.

    6. The patient is responsible for the mailing of his own urine.
      A mailing container is provided by Dr's Data.

    Paravenous infiltration of DMPS is harmless, but creates an itching sensation at the injection site for half an hour or so.
    DMPS appears to clear the vascular system and the connective tissue of heavy metals.

    ... as the connective tissue becomes "cleaned up" more heavy metals move from the intracellular space into the extracellular space (if the body burden of heavy metals is high) .

    ... the following reactions are often seen:
    The patient feels better for several days after the injection, then starts feeling bad again.

    Often the patient will have a feeling of "emptiness in his head" and difficulty concentrating for a few days.
    I attribute this to a lack of "good minerals" in his system.

    No mineral supplements should be given 24 hours before and 48 hours after the test.
    Otherwise DMPS will bind to calcium, magnesium, and other "good" minerals and not get to the mercury.

      • The urine test results come back after three weeks or so.

      • The patient is instructed to come back after four weeks.

      • If any of the toxic metals are elevated above normal or mercury excretion is more than 1 mcg/24 hours, the next injection is given.

      • I recommend to repeat the urine test at the time of the third shot (two months after beginning of treatment) .
        By mobilizing mercury, copper, nickel, etc. from the intracellular space to the extracellular space and from there out of the system, the heavy metal related symptoms of the patient can be temporarily aggravated (i.e. joint pains, depression, fatigue, etc.) . However, this is transient.

    In my experience, the patient will always feel better within three to four weeks following the shot (that means better than before beginning of treatment). In my experience, dentists have required six to eight treatments to get the heavy metal burden down to "normal". They then require a shot every four to six months or so to stay current. Alternately, they can use oral chelation with chlorella (8 caps/day). People that had exposure to amalgam through their fillings will typically require three to five injections. People who have never had amalgam fillings, but show evidence or suspicion of heavy metal toxicity through other sources, typically require one to two injections.

    I have not observed any serious side effects.
    Side effects are occasionally observed such as temporary lowering of blood pressure, allergic reactions, and skin rashes.
    DMPS is not mutagenic, seems to have no teratogenic effects, and is not carcinogenic.

    Max Daunderer, M.D., prefers the Russian made version of DMPS called Unithiol, which comes in a 5 ml 500 mg ampule. This agent is preferably injected intramuscularly, half ampule in each buttock. The excretion of heavy metals caused through this approach is much more gradual than after the IV DMPS and not suitable to use in conjunction with the urine challenge test. However, it is good to use this approach at times when no urine test is planned for. I am not aware of sources for Unithiol in the U.S.A. However, in Europe this agent is much less costly than the German made product18.

    I firmly believe at this point in time that there are no alternatives to the DMPS treatment.
    I have not seen any clear evidence that any of the other proposed detox programs result in the same clinical improvements including the use of DMSA, BAL, and D-penicillamine.

    Chlorella speeds up the cleaning-up process, but can temporarily lead to detox-related unpleasant symptoms.
    Chlorella seems to be the ideal agent to stay current with a low toxic metal burden and helps to survive these times of toxic overexposure from so many different sources.



    Amanda: Mercury: Chelating with DMPS. INDEX
    https://www.amandashealthjournal.com/mercury-chelating-dmps/

    I’ve spent countless hours researching mercury chelation.
    There are so many differing views on how to do it. For example, some doctors will want to test your mercury levels and so they have you do a urine provocation test, where you take DMSA or some other chelator – in large and harmful amounts – and look to see how much mercury is excreted afterwards. I did this back in 2009 and my level was off the chart, literally.

    Mercury toxicity is such a tricky monster because your symptoms could be something else – hypothyroidism, adrenal fatigue, poor digestion, systemic candida, neuropathy – or you could be suffering the effects of mercury exposure. Provocation tests are sometimes not accurate, cause redistribution after whatever is not excreted becomes reabsorbed, and are not recommended.

    Heavy metal toxicity and chelation are topics that I will discuss with much more frequency.
    I have a long history with this condition and want to share it with you, but I also want to give you the experience of successful chelation, and I’m not there yet. I am using Andy Cutler’s protocol. He is a Ph.D. who wrote Amalgam Illness: Diagnosis and Treatment. His site is http://www.noamalgam.com/.

    EDIT 1.12.13 : I stopped the Cutler chelation protocol last summer after only a few months.
    I was taking low doses in the correct way, but noticed increased/new symptoms due to too much mobilization and not enough excretion. It is also possible that by attempting to remove the mercury, I began to feel the effects of possible Lyme infection. Please see the post on Chronic Lyme Disease of Mercury Poisoning? and/or Dr. Chris Shade and the new way to test mercury toxicity levels.

    I write this post today because I came across a site that, as it did a few years ago when I saw it for the first time, gives me hope. It’s a site created by a lawyer who finally figured out that mercury was her deal. It took years, but she (I think it’s a she) improved tremendously, mostly with DMPS chelation. I emailed her back then but got no reply – no doubt she’s been besieged by emails over the years by people who are starting out on the chelation journey.

    It’s very important to keep in mind that I.V. DMPS is never the way to go, but oral DMPS does work for some – if taken the right way (i.e. on a timed schedule for a few days on, and then some more days off – these are called rounds). The other useful chelators a la Andy Cutler are DMSA and alpha lipoic acid.

    The site is http://www.mercurylife.com. LINK
    Check out her story – it is very well documented, thanks to her many journals.
    Here is a little of what she writes on how DMPS worked better for her than DMSA:

    Overall, I think DMPS has several advantages over DMSA, the principal advantage being that it is a much more effective mercury chelator — it has made all the difference in the world in my own recovery. Actually, many doctors believe that, when used properly, DMPS actually has less side effects than DMSA, and from my 1.5 years of experience with both types of chelators, I would definitely agree with this.

    Other advantages include the fact that DMPS appears to remain in the body for a longer period of time than DMSA.
    Also, DMPS acts more quickly than DMSA, probably because its distribution is both extracellular (outside of cells) and intracellular (within cells), where DMSA appears to be distributed only extracellularly.

    And, DMPS is available for intravenous and Drawing_intestinesintramuscular use, as well as in oral form, where DMSA is only available in oral form.

    Furthermore, DMSA appears to cause more yeast problems than DMPS, possibly in part because more DMSA remains in the gut than DMPS (only about 20% of an oral dose of DMSA is absorbed from the GI tract — the other 80% travels through the GI system unabsorbed — versus about 50% for oral DMPS). This may draw more mercury into the gut, and thus increase the presence of yeast (causing a yeast “flare-up”) due to the sequestering effects of yeast described previously.

    Also, a higher percentage of DMPS appears to be excreted through the kidneys than with DMSA, which presents certain advantages over the liver/bowel route, such as avoiding the “enterohepatic reuptake loop.”



    Protocol: Mercury Detoxicfication, Mercola. INDEX
    http://www.mercola.com/article/mercury/detox%5Fprotocol.htm
    NO date or author available in text or page code.

    1. Diet
    Avoid all sugar and milk, limit all processed foods and most grains, especially wheat. ...

    It will be important to have a high protein diet as the sulfur bearing amino acids in the protein will greatly facilitate detoxification. Do NOT attempt to fast during DMPS mercury detoxification. If you are a vegetarian you will be at HIGH risk for complications from DMPS unless you have a large amount of protein.

    Whey protein can be used as a supplement as it is high in glutathione and branched chain amino acids.
    Two large tablespoons are used per drink and that can be taken once a day and twice a day for the week prior to DMPS chelation.

    Autistic children can't use this product as it contains casein.
    They can use pure branched chain amino acids.
    You can start with one capsule twice daily and mix with food.
    Work up to two capsules twice a day for the week prior to DMPS chelation.

    2. Beneficial Bacteria
    Take one quarter to one half teaspoon once a day of a high potency high quality strain.
    It is vital to have an optimized bowel flora for detoxification.

    3. Maintain two to three bowel movements per day
    If you are not having this many bowel movements make certain that your thyroid status has been checked.
    It is very common for mercury to affect the thyroid.
    If your thyroid function is fine then you should add some magnesium.

    If you are on long-term magnesium it is important to take some calcium with it or after awhile you will develop an imbalance in your calcium magnesium ratio which could result in severe cramping.

    Freshly ground flax seed several teaspoons per day will facilitate intestinal movement and also contribute some healthy essential fatty acids.

    4. Unload the connective tissue with Chlorella or ProChitosan
    Chlorella and ProChitosan are an important part of the detoxification program, as approximately 90% of the mercury in our bodies is eliminated through the stool. Chlorella is an algae and, unlike Protchitosan, has protein high levels of chlorophyll and other nutrients which can be used for nourishment.

    The chlorella powder is the most cost effective approach but some people will prefer the tablets or capsules for convenience. A simple way to dissolve the powder is to place it in a container with a lid partially filled with water. Then tighten the lid and shake to dissolve and drink the solution.

    Caution: About 30% of people can't tolerate chlorella.
    This may be due to optimized function of the enzyme cellulase.
    If you are unable to tolerate this it would be wise to consider adding an enzyme with cellulase in it to help digest the chlorella.

    Dose: One can start out with a one quarter of a teaspoon of the powder (one 500 mg tablet) once a day initially to confirm that there is no hypersensitivity present. Work up slowly over one to two weeks to a dose of one teaspoon (ten tablets or capsules) per day. Once you tolerate this dose you are able to use it to bind the mercury.

    Use this dose starting two days prior to your chelation and for one day afterwards.
    The chlorella will thoroughly coat your intestine and bind like a sponge to any mercury that the DMPS liberates into the gut.

    The above dose is based on a 150 pound adult.
    If you are using the program for children reduce the dose proportionately.
    (So a 30 pound child would have have 30/150 or 1/5 (20%) of the dose).


    Caution: If at any time one develops nausea or starts "burping up" the chlorella taste then the chlorella should be stopped immediately as a food sensitivity is developing which will only worsen if you continue taking it. If this happens you should switch to ProChitosan. This binds similarly to mercury. Its dose is dependent on your bowel movements.

    If you have one bowel movement a day or less you should start two days prior to the DMPS.
    If you have two or more bowel movements, you can start 24 hours prior to the DMPS.
    Stay on it for 24 hours after the DMPS. So you will be on it either two or three days.
    The dose is two capsules 3 times a day. Be sure to drink it with plenty of water and increase magnesium if constipation develops.

    Porphrazyme from Biotics Research is another alternative to chlorella that many clinicians have had success with in mercury detoxification.

    5. Start Garlic or MSM
    It would be wise to start on garlic regularly to enhance sulfur stores.
    Use the food, rather than the supplement garlic.
    Try to get in 3 cloves per day, but decrease the dose if your odor becomes socially offensive.

    Again, as indicated in the chlorella section above, children will have proportionately lower doses.

    MSM is a form of sulfur which will help your body to remove the mercury.
    The initial dose is one capsule twice a day. Increase by one capsule a day until you are at 3 capsules twice a day.
    If you have root canals and are chronically sick you may want to increase to five capsules three times a day.

    6. Start Cilantro
    Cilantro will help mobilize mercury out of the tissue so the DMPS can attach to it and allow it to be excreted from the body.
    The best form of cilantro is a tincture available from Dragon River (505-583-2348).

    The dose is one dropper applied on the wrists and rubbed in twice a day for the two weeks preceding the DMPS IV.
    It is used the morning prior to the DMPS chlelation but can be stopped for the following two weeks.
    The tincture is also particularly useful for any joint pain and could be rubbed on the joint that is hurting as an alternative.

    You can also augment the tincture with using the herb.
    It is not as potent, but certainly will add to the program.
    However, like chlorella, many people are sensitive to oral cilantro.
    So, if you develop any nausea or discomfort after eating cilantro do not use it orally.

    7. Mineral Replacement
    It is important to have a generally healthy mineral base.
    The body works better with toxic metals than no metals at all.
    Enzymes have certain binding sites that require a metal for them to perform their function as a catalyst.
    When you are deficient in magnesium, sodium, zinc and other minerals, the body does not let go of the toxic metals very easily.

    Selenium and zinc are particularly important trace minerals in mercury detoxification and should be used for most people.

    Generally the citrate form of minerals works quite nicely unless one has a low blood phosphorous level.
    It is important to not take copper or iron though unless a clinician has examined a hair analysis and or blood work and recommended these minerals. Thorne Research has Citramins II which is citrated minerals without copper or iron.

    Hydrochloric Acid:
    If you do not have a sufficient amount of hydrochloric acid secreted by your stomach then it will be very difficult to ionize mineral supplements to absorb them properly. There is a hydrochloric acid reflex present on the lowest rib approximately one inch lateral to the midline. If this area on the rib is tender to palpation there is a strong likelihood the person is deficient in hydrochloric acid and would benefit from supplementation.

    This is especially common in individuals over 50 years old, and also in individuals with food allergies.
    One to 6 capsules or more of Betaine hydrochloride is generally taken with the first bite of every meal for proper digestive support. The Betaine can be discontinued once the reflex point in non-tender to deep palpation.

    Monitoring Your Mineral Dosing
    It will be very important to monitor your mineral levels during the detoxification program.
    This should be done initially and at least every 6-12 weeks. I only recommend two labs to do this work.
    Trace Elements and Analytical Research as they are the only two labs that do not wash the hair samples prior to analysis.

    8. Digestion and Gall Bladder Support for Autism
    Liver and gallbladder congestion are major issues in states of toxicity.
    To insure that your gallbladder bile flow is functional add magnesium taurate or taurine, butyric acid (Butryex 559-433-3110)

    The dose of the Butyrex initially is 1/8-1/4 of capsule.
    Gradually increase the dose to 5 capsules 3 times daily.
    The Butyrex has an offensive odor which is lessened by keeping it in the freezer.
    Additionally inserting the powder in applesauce, raw honey or elderberry cough syrup may improve compliance.

    Digestive enzymes (containing lipase) and CCK (stimulates contraction of the gall bladder) can be used one hour after meals containing fat. CCK is taken after dinner (high fat meal).

    • young children 1/4 tablet
    • older children 1/2 tablet
    • teenagers 1 tablet
    • adults 2 to 4 tablets

      Your ability to clear toxins will be impaired if you do not have proper fats to support digestive function.
      Your diet should contain adequate fat from unprocessed pure oils. ...

      • sunflower
      • safflower
      • sesame

        OR fats naturally found in foods:

      • seeds
      • nuts
      • avocado
      • free range organic poultry, eggs, or meats


    9. Antioxidants
    Vitamin C and E.
    It would be wise to take Unique vitamin E one capsule per day and about 250-500 mg of vitamin C with each meal.
    If you are exercising aggressively you can take 1000 mg of C 15-30 minutes prior to exercising.
    It is also wise to consider adding 2-4,000 mg of Vitamin C powder to a half gallon of water and drinking that throughout the day.

    It will be VERY important to take 2000 units (typically five of the 400 unit capsules) of vitamin E the day of and the day after the DMPS injection as this will decrease the side effects of the detoxification reaction considerably. You can also take 1-2 grams of vitamin C immediately prior to the DMPS injection.

    10. Start Monthly DMPS Injections, Suppositories or Transdermal
    You should not have DMPS if you still have amalgam fillings.
    If they have been removed the injections can be started on a monthly basis.
    Collection of the urine is then down to analyze how much mercury is being excreted.
    One must urinate completely prior to the injection.

    I perform the analysis at 90 minutes as that is most convenient, but others do four or 24 hour collections.
    The DMPS injections are generally given about six times or until the level drops into single digits or you are feeling better.

    For pediatric patients
    ... I don't recommend DMSA mercury chelation.
    Since an IV is such a traumatic event for most children it is probably wise to use a rectal suppository version of DMPS which is available from most compounding pharmacists. Another alternative is to apply the dose transdermally with DMSO. This is very similar to the way that the hormone secretion is being used for many autistic patients.

    The dose is 5 mg of DMPS per kg of body weight and is generally given once a month.
    The urine collection for pediatric patients incorporates a bag to collect the urine for mercury analysis.

    11. DMPS Alternative
    Some people do not tolerate DMPS well.
    This is especially true for those who have damage in the central nervous system, such as those with MS or ALS or children with fragile brain architecture. If this is the case there are several options.

    PCA (peptid clathrating agent) spray can be used.
    The dose is 4 sprays under the tongue every day or every other day. ...


    Technical: The Andy Cutler Protocol.
    DMPS Notes.
    INDEX
    http://www.livingnetwork.co.za/chelationnetwork/chelation-the-andy-cutler-protocol/

    DMPS is used for mercury, but will also chelate arsenic.

    It chelates extracellular mercury or body burden.
    It is taken according to its half-life every six to eight hours in Dr Culter’s protocol.

    DMPS, is a powerful chelator especially beneficial during times of acute toxicity.
    It is a synthetic compound. Taken without caution and in high dosages, as with challenge tests, it can cause too much mercury to be pushed into the kidney and liver (especially if these organs are not working well), and can possibly damage them. You should not take DMPS, or any chelator, intravenously. Taken orally however, in accordance with Andy Cutler’s protocol, it can prove very beneficial, especially for those that do not tolerate DMSA or ALA well.

    Most people do fine without DMPS, using DMSA and ALA only.
    However if you have a problem with DMSA, then use oral DMPS at frequent low dosages and then later add ALA.
    DMPS requires a script from an appropriate doctor in some countries. ....

    Other compounds that can chelate or move metals around, BUT SHOULD NOT BE USED:

    CILANTRO – Coriander/Dhania – although this is a natural chelator known to cross the blood-brain barrier, its half-life and method of action are unknown at present. Therefore, you are advised to steer clear of methods advising its use until its safety has been properly evaluated.

    CHLORELLA – is not a chelator as it contains only one thiol group (sulfhydryl group).
    It can pick up mercury and move it around, but it does not strictly chelate it and hold onto it.
    This can cause a lot of oxidative damage as mercury ‘bounces around’.

    Chelators are dithiols (they contain two sulfhydryl groups) and hold on to mercury tightly and safely.
    Beware of protocols using chlorella for chelation.

    1) DMPS Challenge test:
    WARNING: Do not do challenge tests!
    Many health practitioners offer provoked or challenge tests to supposedly measure heavy metal levels in the body via urine.
    This is very dangerous to mercury toxic people and should be avoided at all costs.

    The most common suggestion is the DMPS challenge test, whereby a large amount of DMPS is delivered via a single-dose IV injection (Intra-Venous). This causes the body to mobilize a lot of mercury (and other metals), that was previously bound safely within storage sites in the tissues. It is drawn out of the tissues like a sponge and dumped into the blood stream. If your body is unable to deal with this unexpected toxic load, long-term consequences can follow. Many people have had terrible adverse effects and others have experienced permanent damage from these tests. Dr Andy Cutler advises strongly against this test and encourages hair elements testing instead.

    For more information of the dangers of the challenge test visit: DMPS Backfire and Dr Cranton’s website.
    http://www.dmpsbackfire.com/default.shtml

    DMPS has been recognized to have excellent use in cases of acute metal toxicity, but when used as a ‘challenge test’ the results do not yield a lot of valuable information and even if you do decide to do a ‘challenge test’ after properly researching it, the overall test results cannot be considered as meaningful, since mercury is mobilized and ‘redistributed’ throughout the body in indiscriminate patterns, making scientific comparisons impossible. DMPS does not cross the blood-brain barrier or cell membranes, so it yields NO information about levels in the brain, organs and cells.

    Challenge tests are discouraged as the results are not informative anyway.
    The readings will come from mobilizing mercury which is not released in any consistent manner.
    Each test result can vary in the extreme, even with the same person, skewing information.

    More importantly:
    Never, ever take any chelator in any form if you have any mercury still inside your mouth!
    Many doctors/dentists advise this prior to removal.



    Article : Article : Use of liposome encapsulated DMPS .... INDEX
    https://cwru.pure.elsevier.com/en/publications/
    use-of-liposome-encapsulated-sodium-23-dimercapto-propane-sulfona-2 J. R. Behari, S. Gupta, S. Srivastava, R. C. Srivastava
    Journal of Environmental Science and Health
    - Part A Environmental Science and Engineering
    Volume 25, Issue number 6, Pages 597-610 --- Published - 1990

    Abstract
    Sodium-2,3-dimercaptopropane sulfonate (DMPS) is a potent thiol chelating drug used against heavy metal intoxication.
    With a view to enhance its efficacy at low dose DMPS was encapsulated in liposomes made up of equimolar egg phosphotidylcholine and cholesterol and then administered to mice loaded with cadmium.

    Both the free as well as liposomal drug enhanced urinary excretion of cadmium.
    While fecal excretion of cadmium was enhanced only by liposomal drug, liposomal DMPS was effective in mobilizing more cadmium from blood, liver, kidney and spleen by day 3 of treatment, Liposomal DMPS was also able to decorporate some cadmium from cadmium binding proteins with low molecular weight corresponding to metallothionein.

    ... It has long been acknowledged that sulfhydryl-containing compounds have the ability to chelate metals.
    The sulfur-containing amino acids

        methionine and cysteine, cysteine’s acetylated analogue N-acetylcysteine, the methionine metabolite S-adenosylmethionine, alpha-lipoic acid, and the tri-peptide glutathione (GSH)
      all contribute to the chelation and excretion of metals from the human body.



    Product: DMPS, Living Supplements, SA INDEX
    https://www.livingsupplements.com/
    Strengths available in 1mg to 100 mg 

    14 Pinetree Crescent, Vredehoek, 
Cape Town, 8001, South Africa

    1. DMPS 5 mg
      USA $32.44 (2017-11) -- $38.13 (2018-03) --- 80 size # 0 clear capsules
      Ingredients
      DMPS 5 mg (as 2,3-Dimercapto-1-propanesulfonic acid salt monohydrate)
      Vitamin C (as ascorbic acid, derived from a non-GMO corn source) 50mg (% daily value 83%)
      with Vegetable cellulose capsules & microcrystalline cellulose, and nothing else added.
      Manufactured in a GMP-certified facility using USP-grade raw materials only.
      NB. Please keep your products tightly closed, as they contain an oxygen absorber to keep them from oxidizing.
      This product was added to our catalog on Thursday 06 March, 2014.

    2. DMPS 10 mg
      USA $48.84 (2017-11) -- $57.41 (2018-03) --- 80 size # 0 clear capsules
      Ingredients
      DMPS 10 mg (as 2,3-Dimercapto-1-propanesulfonic acid salt monohydrate)
      Vitamin C (as ascorbic acid, derived from a non-GMO corn source) 50mg (% daily value 83%)
      with Vegetable cellulose capsules & microcrystalline cellulose, and nothing else added.
      Manufactured in a GMP-certified facility using USP-grade raw materials only.
      NB. Please keep your products tightly closed, as they contain an oxygen absorber to keep them from oxidizing.
      This product was added to our catalog on Saturday 22 June, 2013.

    3. DMPS 15 mg WITHOUT Vit C
      USA $59.77 (2017-11) -- $70.26 (2018-03) --- 80 size # 0 clear capsules
      Ingredients:
      DMPS 15mg (as 2,3-Dimercapto-1-propanesulfonic acid salt monohydrate)
      with Vegetable cellulose capsules & microcrystalline cellulose and nothing else added.
      Manufactured in a GMP-certified facility using USP-grade raw materials only.
      NB. Please keep your products tightly closed, as they contain an oxygen absorber to keep them from oxidizing.
      This product was added to our catalog on Thursday 17 March, 2016.

    4. DMPS 25 mg
      USA $74.42 (2017-11) -- $87.48 (2018-03) --- 80 size # 0 clear capsules
      Ingredients:
      DMPS 25mg (as 2,3-Dimercapto-1-propanesulfonic acid salt monohydrate)
      Vitamin C (as ascorbic acid, derived from a non-GMO corn source) 50mg (% daily value 83%) with
      Manufactured in a GMP-certified facility using USP-grade raw materials only.
      NB. Please keep your products tightly closed, as they contain an oxygen absorber to keep them from oxidizing.
      This product was added to our catalog on Saturday 22 June, 2013.

      Additional Information:

      Time zone : GMT +2 hours Contact Form: ... page=contact_us
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      and instead request that you make use of the contact form...
      Please bear in mind the time zone differences whilst awaiting a reply
      i.e. we generally won't be able to respond between 10pm and 8am GMT +2 hours.

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      International parcels are first couriered to the UK, where they are re-shipped globally ....

      Both Registered and non-registered options are sent via the same International First Class Air Mail and have the same time-frames.

      Shipping Time: Maximum 5 weeks, if not received, contact them.
      CANADA: Ave. 3-5 weeks, (sometimes 6 weeks as spend long periods in Canada customs)
      No tracking options

      Canada (max 3 of same product at one time)



      - Legal -: USA FDA Considerations. INDEX
      https://www.chelationwatch.org/reg/dmps.shtml
      Stephen Barrett, M.D.
      This article was revised on September 30, 2016

      It is legal to compound any bulk drug substance that the FDA includes in a final list of drugs that can be compounded.
      FDA regulations at 21 CFR 207.3(a)(4) defines bulk drug substance as "any substance that is represented for use in a drug and that, when used in the manufacturing, processing, or packaging of a drug, becomes an active ingredient or finished dosage form of the drug, but the term does not include intermediates used in the synthesis of such substances." No final list has been issued, but the FDA is considering substances that have been nominated for use in compounding under section 503A of the Federal Food, Drug, and Cosmetic Act. McGuff, the American Association of Naturopathic Physicians (AANP), the Alliance for Natural Health, the Integrative Medical Consortium, and the International Association of Compounding Pharmacists have nominated DMPS for the final list of bulk substances that can be used in compounding.

      In June 2016, the FDA Pharmacy Compounding Advisory Committee spent half a day discussing whether DMPS should be the final list. Kathy Robie Suh, MD, PhD, an FDA clinical team leader, stated that her team opposed inclusion because investigation of DMPS had not been been proven safe or beneficial as currently used. Paul Anderson, N.D., who represented the AANP, testified that in 2003, DMPS proved to be life-saving in treating people who had been poisoned with arsenic at a church function. He also estimated that since 1999, one American compounder had processed 10,000 orders for an estimated total of 67,000 doses of DMPS and had received no complaints, and that he himself had administered 5,000 doses to treat people exposed to arsenical pesticides.

      Toxicologist Jeffrey Brent, M.D., Ph.D., testified that the database of the Toxicology Investigators Consortion, to which nearly all practicing toxicologists in the United States use, indicates that since 2010, "not a single medical toxicologist has found a reason to use DMPS in this country, the reason being that we would reserve it for really high quality acute arsenic or mercury poisoning, which . . . is very rare." Possible ways to reduce inappropriate use were discussed, but a compounding pharmacist who was a non-voting member of the Advisory Committee warned that if the FDA found a way to curb such use, DMPS would no longer be sufficiently profitable to manufacturer.

      In the end, the committee voted 8-3 to place DMPS on the final list.
      Several members who voted favorably expressed discomfort but decided that the rare need for emergency use for arsenic poisoning outweighed the risks people of getting DMPS inappropriately. I do not agree. It seems to me that there should be a way to make DMPS available for emergency use without leaving thousands of people per year at the mercy of practitioners who misdiagnose toxicity.

      In September 2016, the FDA announced that "to avoid unnecessary disruption to patient treatment" while the FDA considers the nominated substances, it would not act against a nominated product provided that it is manufactured by an establishment registered with the FDA, fulfills certain other conditions, and does not appear to present significant safety risks.

      The FDA's final determination will not be made until (a) input from the advisory committee process has been considered, (b) all reviews have been finalized, (c) consultation with the United States Pharmacopeia has occurred, and public comment has been considered through notice and comment rulemaking. ...



      LINKS from Lenntech, and others. INDEX
      http://www.lenntech.com/

      LINK 2: http://rmalab.com/sites/default/files/tests/instructions/20140107_CI_UrineElement.pdf
      Rocky Mountain Labs Clinical Info report for Professionals, 2014-01-07
      An assessment of the benefits and limitations of various test protocols.

      Phone: +31 152 610 900 --- info@lenntech.com


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      I gathered and researched this data, mediated with the Grace of God through prayer, first, as a benefit in my interest in exploring available digital information which would acquaint me with the overall content related to the subject. I have found that God is ALWAYS available when we are Reverent in our Asking, open-minded in our Listening, and, Assertive in our Choice of Action. Doctors did not expect me to survive birth. In the past 25 years, medical and health "experts" have cautioned or directed me, more than 14 times, that I had little time left to live, or would die ... because THEY did not understand my challenges, were not motivated to professionally diagnose, or, chose to superstitiously recall as absolute previously flawed training. I am still alive beyond age 70. With the assistance of God, my Personality, the research and lack of dismissiveness of a number of persons ... I have found resolution to numerous health challenges. This has enabled me to assist many others who had been abandoned. May it also empower you. This is one document which you may find helpful as a BASIC introduction to the subject.