Enhancer

EDTA --- Ethylenediaminetetraacetic acid
aka. Sodium calcium edetate

Binding of metal ions.

2017-12


      Top INDEX
    • Basics: Enhancement.
    • About: EDTA Calcium.
    • Industry: Uses of Ethylenediaminetetraacetic acid.
    • Medical: Uses of Ethylenediaminetetraacetic acid.
    • .
    • Assess: Focus Group Decision Document for EDTA.
    • Report : The Business of Chelation.

      Product Possibilities, NOT Recommendations.
    • Product: ToxDetox - Glutathione & EDTA synergy.
    • Product: KelaminHM 1500, Chelation Health Products.
    • Product: Protect EDTA, Nutristand.
    • Product: Oral Drops.
    • Product: EDTA, Natural, Arizona Natural Products.
    • -LINKS: from Lenntech, and others.
    • -Focus-: Monographs on Toxins and Enhancers.

Enhancement is a Potential, not a Guarantee.
With awareness, patience, and choice we can optimize.
Water and air are fundamental to our form of life.
Too much of either leads to death; air = embolism; water = drowning.
Too little of either leads to death; air = suffocation; water = dehydration.
The healthy Balance for each of us is dynamic and personal.




Basics: Enhancement. INDEX
http://www.advance-health.com/chelation.html

The objective of oral chelation is to improve ones health and nutritional status by replacing toxic heavy metals with essential elements.

Dr. Walter Blumer, M.D. of Switzerland has documented the results of EDTA heavy metal detoxification treatment for over 20 years. He showed that patients receiving a minimum of 30 oral treatments experienced an 85% reduction in cardiovascular events and a 90% reduction in new malignancies when compared to individuals in the same village who did not receive the treatments. Prof. Johan Bjorksten, creator of the crosslinkage theory of aging, estimated that the average human life span could be increased by 15 years as a result of chelation therapy. This estimate was based on the results from animal studies. The theory is that removing heavy metals reduces the crosslinking that contributes to the aging phenomena.

Garry Gordon, M.D. of the Gordon Research Institute is one of the proponents of oral chelation therapy with EDTA. Dr. Gordon claims to personally have taken a minimum of 800 mg. of EDTA per day for the past ten years. He considers this to be a low dose. He also advocates the use of malic acid to chelate excess iron and aluminum. Dr. Gordon suggests that dosages of EDTA of 800 to 5000 mg. per day should be considered depending on the body weight and kidney status of the patient. Kidney health is important because the excretion of lead and mercury in the urine is toxic and stressful to the kidneys. He bases his recommendations on the research conducted by Abbot Laboratories. Abbot claims that 1000 mg. of EDTA per 35 pounds of body weight was the correct dose for treating asymptomatic lead intoxication orally, based on FDA sanctioned studies. Incidentally, Dr. Gordon claims that his health has continued to improve over the past ten years. He is now 67.

One concern with chelation therapy in general is that chelating agents are not as specific as we would like and are likely to remove essential trace minerals as well as toxic metals. Trace mineral replacement therapy is essential when doing any form of chelation. Trace mineral therapy is important on its own as well since the essential minerals compete with toxic metals for binding sites. In other words, when ones body is properly mineralized, the absorption and toxicity of heavy metals is greatly reduced. It is my view that the majority of us are malnourished in terms of minerals and trace minerals.

... chelation agents include EDTA, Vitamin C (Ascorbic Acid), methionine, cysteine, malic acid, DMSA (dimercapto succinic acid) and Garlic. In addition, toxic heavy metals can to some degree be displaced by the essential minerals and trace minerals. This is particularly interesting in the case of iodine when used in high doses (Iodoral).

There is a controversy as to whether EDTA should be taken with meals or away from other food.
Paradoxically, there is evidence that EDTA enhances the uptake of some nutrients such as zinc and iron.
Logically, it would seem that the consumption of a chelating agent with food might bind the essential trace minerals and limit absorption. Which approach to take is guesswork at present.




About: EDTA Calcium. INDEX
https://en.wikipedia.org/wiki/Ethylenediaminetetraacetic_acid
LINK 2: https://en.wikipedia.org/wiki/Sodium_calcium_edetate

Ethylenediaminetetraacetic acid is the chemical name; for the medication, use Sodium calcium edetate.

Its usefulness arises because of its role as a hexadentate ("six-toothed") ligand and chelating agent, i.e., its ability to "sequester" metal ions such as Ca2+ and Fe3+.

After being bound by EDTA into a metal complex, metal ions remain in solution but exhibit diminished reactivity.
EDTA is produced as several salts, notably disodium EDTA and calcium disodium EDTA.




Industry: Uses of Ethylenediaminetetraacetic acid. INDEX
https://en.wikipedia.org/wiki/Ethylenediaminetetraacetic_acid

In industry, EDTA is mainly used to sequester metal ions in aqueous solution.
In the textile industry, it prevents metal ion impurities from modifying colors of dyed products.
In the pulp and paper industry, EDTA inhibits the ability of metal ions, especially Mn2+, from catalyzing the disproportionation of hydrogen peroxide, which is used in "chlorine-free bleaching".

In a similar manner, EDTA is added to some food as a preservative or stabilizer to prevent catalytic oxidative decoloration, which is catalyzed by metal ions.

In soft drinks containing ascorbic acid and sodium benzoate, EDTA mitigates formation of benzene (a carcinogen).

The reduction of water hardness in laundry applications and the dissolution of scale in boilers both rely on EDTA and related complexants to bind Ca2+, Mg2+, as well as other metal ions. Once bound to EDTA, these metal centers tend not to form precipitates or to interfere with the action of the soaps and detergents. For similar reasons, cleaning solutions often contain EDTA.

In a similar manner EDTA is used in the cement industry for the determination of free lime and free magnesia in cement and clinkers.

The solubilization of ferric ions, at or below near neutral pH can be accomplished using EDTA.
This property is useful in agriculture including hydroponics. However, given the pH dependence of ligand formation, EDTA is not helpful for improving Fe solubility in above neutral soils. Otherwise, at near-neutral pH and above, iron(III) forms insoluble salts, which are less bioavailable to susceptible plant species. Aqueous [Fe(edta)]- is used for removing ("scrubbing") hydrogen sulfide from gas streams. This conversion is achieved by oxidizing the hydrogen sulfide to elemental sulfur, which is non-volatile.

EDTA can also be used to test for bioavailability of heavy metals in sediments.

EDTA may influence the bioavailability of metals in solution, which may pose concerns regarding its effects in the environment, especially given its widespread uses and applications.

While EDTA serves many positive functions in different industrial, pharmaceutical and other avenues, the longevity of EDTA can pose serious issues in the environment. The degradation of EDTA is slow. It mainly occurs abiotically in the presence of sunlight.




Medical: Uses of Ethylenediaminetetraacetic acid. INDEX
https://en.wikipedia.org/wiki/Ethylenediaminetetraacetic_acid
LINK 2: https://en.wikipedia.org/wiki/Sodium_calcium_edetate

Sodium calcium edetate is in the chelating agent family of medication.
It works by binding a number of heavy metals which allows them to leave the body in the urine.

A specific salt of EDTA, known as sodium calcium edetate, is used to bind metal ions in the practice of chelation therapy, e.g., for treating mercury and lead poisoning. It is used in a similar manner to remove excess iron from the body. This therapy is used to treat the complication of repeated blood transfusions, as would be applied to treat thalassaemia.

    Potential Benefits include
    • to treat lead poisoning,
    • reducing plutonium toxicity,
    • chelating other other heavy metals,
    • serves as a preservative,
    • to remove inorganic dental debris,
    • anticoagulant,
    • reducing bacterial growth,
    • evaluating kidney function,
    • analysis of blood.

Dentists and endodontists use EDTA solutions to remove inorganic debris (smear layer) and lubricate the canals in endodontics. This procedure helps prepare root canals for obturation. Furthermore, EDTA solutions with the addition of a surfactant loosen up calcifications inside a root canal and allow instrumentation (canals shaping) and facilitate apical advancement of a file in a tight/calcified root canal towards the apex.

It serves as a preservative (usually to enhance the action of another preservative such as benzalkonium chloride or thiomersal) in ocular preparations and eyedrops.

In evaluating kidney function, the complex [Cr(edta)]- is administered intravenously and its filtration into the urine is monitored. This method is useful for evaluating glomerular filtration rate.

EDTA is used extensively in the analysis of blood.
It is an anticoagulant for blood samples for CBC/FBEs.

EDTA is a slime dispersant, and has been found to be highly effective in reducing bacterial growth during implantation of intraocular lenses (IOLs).




Caution: Common & Rare Side Effects. INDEX
https://en.wikipedia.org/wiki/Ethylenediaminetetraacetic_acid
LINK 2: https://www.evenbetterhealth.com/heavy-metal-poisoning-treatment.php

    Common side effects include
    • pain at the site of injection,
    • kidney problems,
    • diarrhea,
    • fever,
    • reproductive and developmental effects,
    • cytotoxic and weakly genotoxic,
    • muscle pains, and
    • low blood pressure.

Side Effects:
EDTA exhibits low acute toxicity with LD50 (rat) of 2.0 g/kg to 2.2 g/kg.
It has been found to be both cytotoxic and weakly genotoxic in laboratory animals.
Oral exposures have been noted to cause reproductive and developmental effects.
The same study by Lanigan also found that both dermal exposure to EDTA in most cosmetic formulations and inhalation exposure to EDTA in aerosolized cosmetic formulations would produce exposure levels below those seen to be toxic in oral dosing studies.

In many industrial wastewater treatment plants, EDTA elimination can be achieved at about 80% using microorganisms.

Several bacterial strains isolated from sewage treatment plants efficiently degrade EDTA.
Specific strains include Agrobacterium radiobacter ATCC 55002 and the sub-branches of Proteobacteria like BNC1, BNC2 and strain DSM 9103.

The three strains share similar properties of aerobic respiration and are classified as gram-negative bacteria. Unlike photolysis, the chelated species is not exclusive to Fe(III) in order to be degraded. Rather, each strain uniquely consumes varying metal-EDTA complexes through several enzymatic pathways.

Agrobacterium radiobacter only degrades Fe(III) EDTA while BNC1 and DSM 9103 are not capable of degrading Fe(III) EDTA and are more suited for CaEDTA, BaEDTA, MgEDTA and MnEDTA. EDTA complexes require dissociation before degradation.

A Caveat for all Chemical Chelator Usage.

hese most commonly known chelators need to be taken in fairly high doses to be truly effective.
Because of this, side effects are virtually unavoidable. Accordingly, these potent pharmaceuticals cannot be taken for an extended period of time (Goodman & Gilman).

As well, because of the high doses needed with these chelators, essential minerals are almost always chelated out of the body as well. Minerals most commonly lost include zinc, magnesium, manganese, molybdenum, and selenium, which then need to be replaced.

Toxic metals are often stored in the brain, and none of the above-mentioned chelators cross the blood/brain barrier.

And last but not least, there has been concern that the metals loosened by the chelating agents are not always properly excreted. Instead, they may be reabsorbed in different parts of the body, causing more damage to the immune system and vital organs. This is why some individuals can remain just as sick after chelation as before, sometimes for years after their "detoxing".




Assess: Focus Group Decision Document for EDTA. INDEX
https://www.epa.gov/sites/production/files/2015-04/documents/edta.pdf -- 28 pgs
January 28, 2004 -- USA Environmental Protection Agency,
Kathryn Boyle at 703-305-6304

The attached science assessment discusses the toxicity of ethylenediaminetetraacetic acid (EDTA) and various ammonium, calcium, copper, iron, potassium, manganese, sodium and zinc salts of EDTA. EDTA is a chelating agent. Its ability to bind heavy metal ions can be used to sequester these trace metals. However, trace amounts of various metals are necessary for the proper functioning of the body. If instead, these minerals were bound to the EDTA, then deficiencies of these trace metals could result. In fact, the toxic effects of EDTA are considered to be related to metal deficiencies, especially a deficiency of zinc.

... Based on its review and evaluation of the available information, EPA concludes that there is a reasonable certainty that no harm will result to the general population, and to infants and children from aggregate exposure to residues of EDTA and its various salts from their uses as ingredients in pesticide products. ... Based on the chelating ability of EDTA and the various ammonium, calcium, copper, iron, potassium, manganese, sodium and zinc salts of EDTA, and the inherent limitations during manufacture of a pesticide product, the Agency will limit the percent of EDTA or any EDTA salt in a formulated pesticide product to 5% by weight.

... EDTA’s ability to complex is used commercially to either promote or inhibit chemical reactions, depending on application.
EDTA has been used extensively as a food additive to sequester trace metals that catalyze the oxidation of oils, vitamins, and unsaturated fats that cause rancidity, flavor changes, and discoloration. ... used in

    food contact surface sanitizing solutions,
    to control the interactions of trace metals in formulations of liquid soaps,

  • cosmetics, and
  • pharmaceuticals, in
  • metal working, in
  • pulp and paper processing, in
  • rubber and polymer chemistry, and in
  • textile processing and dyeing.

... EDTA and its salts are eliminated from the body, 95% via the kidneys and 5% by the bile, along with the metals and free ionic calcium which was bound in transit through the circulatory system. ...

The available ecotoxicity data for EDTA indicate that these compounds are slow to degrade under typical environmental conditions but are not expected to bioconcentrate. EDTA compounds range from practically non-toxic to moderately toxic on an acute basis depending on the salt. Algae and invertebrates are among the most sensitive species based on predictive modeling for acute and chronic endpoints for EDTA, depending on the compound. EDTA and its salts also do not appear to be very toxic for terrestrial wild mammals and adverse effects from reasonably expected agricultural uses are not expected. ...

Tetrasodium EDTA is currently used in food contact surface sanitizing solutions ...

EDTA and several of its salts function as chelating agents in cosmetics. ...
Examples of products containing EDTA chemicals include:

    • bubble baths,
    • bath soaps and
    • detergents,
    • deodorants,
    • facial makeups and lotions,
    • colognes and
    • toilet waters,
    • hair products (shampoos, rinses, conditioners, dyes and colors),
    • nail basecoats and undercoats, and
    • nail creams and lotions.

Calcium disodium EDTA:
Calcium disodium EDTA can be used as a food additive and is permitted for direct addition to food for human consumption, as long as 1) the quantity of the substance added to food does not exceed the amount reasonably required to accomplish its intended physical, nutritive, or other technical effect in food, and 2) any substance intended for use in or on food is of appropriate food grade and is prepared and handled as a food ingredient (21 CFR 172.120). Certification of calcium disodium EDTA when used as a diluent in color additive mixtures for food use is not necessary for the protection of the public heath, and therefore is exempt from the certification under section 721 (c) of 21 CFR 73.1. Calcium disodium EDTA may also be used to promote stability of color, flavor, texture retention, and to retard struvite (mineral) formation. It is also used as a sequestering agent in the production of pharmaceuticals. An acceptable daily intake (ADI) of 2.5 mg/kg calcium disodium EDTA was established by the FAO/WHO (1974). ...

EDTA is also used as

    • a chelating agent in boiler and cooling water,
    • in nickel plating, and
    • in wood pulping processes
    • in detergents for household and textile use,
    • industrial germicides,
    • metal cutting fluids,
    • pharmaceuticals, ...
    • a bleaching agent in color film processing,
    • etching agent in metal finishing
    • semiconductor production,
    • activator in butadiene-styrene co-polymerization,
    • in gas scrubbing,
    • as a component of blood anticoagulants
    (TOXNET 2003).

Trisodium EDTA:
Trisodium EDTA salts are used in

    • detergents,
    • liquid soaps,
    • shampoos,
    • agricultural chemical sprays,
    • pharmaceutical products,
    • oil emulsions, and
    • in textiles to improve dyeing, scouring and detergent operations. ...
    • a metal chelating agent,
    • in metal cleaning and plating,
    • in the treatment of chlorosis,
    • to decontaminate radioactive surfaces,
    • as a metal deactivator in vegetable oils,
    • as an anticoagulant of blood,
    • as an eluting agent in ion exchange,
    • to remove insoluble deposits of calcium and magnesium soaps,
    • as an antioxidant, in the clarification of liquids,
    • in analytical chemistry spectrophotometric titration,
    • to aid in reducing blood cholesterol, and
    • to treat lead poisoning and calcinosis
    (NTP 2003).


In general, EDTA and its salts are mild skin irritants but considered severe eye irritants.

EDTA has been demonstrated to affect inhibition of DNA synthesis in primary cultures of mammalian cells, which may be due to impairment of enzymes involved in DNA replication (Heindorff et al., 1983). EDTA has also been demonstrated to enhance mutagen-induced aberration frequencies in Drosophila melanogaster, Chlamydomonas reinhardi, Neurospora crassa and Zea mays by interfering with the DNA repair process that takes place after exposure to mutagens (Heindorff et al., 1983).

... EDTA is a strong organic acid (approximately 1000 times stronger than acetic acid), and does not appear to occur naturally. It has a high affinity for alkaline-earth ions (for example, calcium and magnesium) and heavy-metal ions (for example, lead and mercury). This affinity generally results in the formation of highly stable and soluble hexadentate chelate complexes. EDTA’s ability to complex is used commercially to either promote or inhibit chemical reactions, depending on application.

... The primary sources of EDTA release to the environment are

    domestic sewage
      (for example, from use in detergents, soaps, and cleaning products)
    and
      industrial effluents (for example, from the bleaching of textiles and paper; processing of photographic material; electroplating; bottle cleaning; and industrial cleaning of pipe and tank systems).
    a food additive, as
      an “inert” ingredient in pesticides, in pharmaceuticals, and in a variety of consumer products.

EDTA is also released through land disposal of products which contain EDTA.
Detergent preparations are probably the predominant source of EDTA found in domestic sewage. ...




Report : The Business of Chelation. INDEX
http://www.smart-publications.com/articles/
the-business-of-chelation-and-why-EDTA-oral-chelation-is-best

Some of the biggest sellers of chelation therapy today are not the purveyors of oral chelation products.
Instead, they are the thousands of IV chelation doctors who treat patients in small clinics.
These doctors belong to organizations like the American College for the Advancement of Medicine (ACAM) and the American Academy of Anti-Aging Medicine (A4M).

The vast majority of these IV chelation doctors are reputable, upstanding medical professionals who are treating patients who are suffering from a wide range of illnesses caused by heavy metal toxicity. In fact, Dr. Garry Gordon, a man whom I highly respect, was one of the founding members of ACAM. Professionals like Dr. Gordon understand that IV chelation is the first step in eliminating acute heavy metal toxicity and that oral chelation is an appropriate follow up recommendation for patients who have completed their IV chelation treatments.

But there is a small minority of IV chelation doctors who tend to downplay and discredit oral chelation.
Their motives vary, but economics most certainly play a role. Why else would they choose to condemn the effectiveness of oral chelation in the face of a mountain of clinical and observational data that clearly supports and affirms oral chelation’s health benefits? Obviously, some of these IV chelation doctors feel threatened by oral chelation. I mean, if you can get the same health enhancing effect by taking a quality oral chelation product for three or four months at a cost of about $100, why would anyone choose IV chelation that costs two or three times as much? ...

Disodium EDTA has become extremely popular amongst various unscrupulous sellers of oral chelation products. There are a few reasons for this. First and foremost, disodium EDTA is probably the least expensive form of EDTA. That means they can purchase it in bulk, pack a lot of it into a capsule, and charge whatever they want to charge for it.

I ’ve seen different companies go in vastly different directions when it comes to marketing disodium EDTA-based chelation products. For example, I know of one company that advertises almost exclusively through the internet using pay-per-click website advertising. They sell capsules containing upwards of 600 mg of disodium EDTA at rock-bottom discount pricing. I know of another company that takes just the opposite tact. They put the miniscule amount of 50 mg of disodium EDTA into each capsule, “enhance” the product by adding all manner of other ingredients, and charge a premium price for a product that will in all probability simply chelate the other ingredients and won’t do you a bit of good!

And to top it all off, neither of these companies mention the dangers involved in using an inferior oral chelation compound like disodium EDTA. Instead, they quote and capitalize on studies that prove the safety and effectiveness of a completely different type of EDTA compound, i.e. calcium disodium EDTA. It is calcium disodium EDTA tablets that can be found in the 1964 Physicians Desk Reference (PDR) as the only medically approved treatment for the removal of lead. On the other hand, disodium EDTA was never medically approved for the removal of toxic heavy metals. Instead, it was approved only as a treatment for hypercalcemia (too much calcium in the blood) via IV administration.

And that’s exactly the dangerous thing about disodium EDTA—it chelates calcium!
... Calcium is an essential mineral to humans and all manner of sickness, disease, and even death can be attributed to calcium deficiency. Chelating calcium, which by the way is one of the most difficult minerals for most people to get their recommended daily intake of, is not only foolish, but dangerous.

Even the FDA has come out publically against the use of disodium EDTA.
On January 16, 2008, the FDA issued a public health advisory to alert patients and health care professionals of the dangers of disodium EDTA and to try to clarify the confusion between these two very different forms of EDTA.

The advisory ... describes documented deaths from people receiving disodium EDTA when they were supposed to receive calcium disodium EDTA. It further urges hospitals and health care practitioners to evaluate their need for stocking disodium EDTA and, if there is no reason to stock disodium EDTA, the FDA urges them to “remove the product from stock to avoid confusion with Edetate Calcium Disodium (calcium disodium EDTA).” ...

Citrus Pectin -- a good fiber
... pectin is a very good source of fiber, but it’s not really a very good heavy metal chelator. ...

“What she (nutrition expert) neglected to mention is that the dosage in the study amounted to taking 50 capsules per day of the pectin product she is hawking!”

... The bottom line with pectin is simple … pectin is a good source of dietary fiber, and I am a firm believer in the importance of fiber in the diet. However, pectin is not a very good chelator, and unless you are prepared to consume massive quantities of pectin, it is not going to do much to remove heavy metal toxins from your body.

Magnesium EDTA -- a good fertilizer
... Please do not put magnesium EDTA into your body -- in any form.
I need to add that last part because I’ve recently come across one company that was selling magnesium EDTA suppositories.

... Magnesium EDTA, like disodium EDTA, is a very weak EDTA chelate and will have a strong affinity for calcium, and I’ve already touched on why that is a very bad idea. To my knowledge, the only commercial use for magnesium EDTA is as an agricultural fertilizer.

Calcium Disodium EDTA -- safe and effective oral chelation
... Since it is already bound with calcium, the EDTA in calcium disodium EDTA will not chelate calcium, ... once in the blood stream, calcium disodium EDTA will quickly shed its calcium bond and chelate toxic heavy metals such as lead or mercury. It’s just a matter of which metal molecule it comes in contact with first.

Like the other forms of oral EDTA, calcium disodium is not particularly well absorbed from the gastrointestinal tract. As stated before, only about 5-15% actually makes it into the cardiovascular system where it can chelate and remove toxins from the blood. However, unlike the other forms of oral EDTA, the unabsorbed portion of calcium disodium EDTA has other health benefits.

Calcium disodium EDTA will chelate toxic heavy metals within the gastrointestinal tract.
Unabsorbed calcium disodium EDTA (the portion that doesn’t make it into the bloodstream) continues to chelate toxins as it passes through the body. It does a great job of cleansing bile acids of toxins which keeps them from being reabsorbed into the body. Toxins in bile are believed to play a prominent role in the development of colon cancer. So, even unabsorbed calcium disodium EDTA contributes to overall general health. ...

What does a quality oral chelation product look like?
... First ... it is going to contain calcium disodium EDTA and it is going to contain it in amounts that are scalable. ...
(and NOT a product) that packs in the daily recommended dose of vitamins and minerals along with the EDTA, (which does not allow for increases in EDTA dosage). ...

Malic acid is the substance that gives grapes and apples their tart taste.
... malic acid is one of the strongest chelators of aluminum known to science, and aluminum in the body is not healthy. As we’ve discussed, calcium disodium EDTA chelates toxic heavy metals like lead. But aluminum, as we all know, is a much lighter metal than lead. A high quality oral chelation product that combines the heavy metal chelator calcium disodium EDTA with the light metal chelator malic acid is a good combination.

Another natural chelator is garlic.
... Garlic has been shown to chelate lead, mercury, and other toxins from the body.
(Garlic odour can be countered) by including parsley powder. ... a few milligrams of parsley powder in an oral chelation formula will ease digestion of the chelating agents and ensure the garlic doesn’t rebound and make one uncomfortable.

With meals or without meals
Another area where the marketing of the various types of oral chelation products has led to consumer confusion is in regards to the best time of day to take oral chelation. The people who sell the “enhanced” versions containing disodium EDTA and a handful of vitamins and minerals say that their products should be taken with meals. The people who consume quality oral chelation products that contain only chelators like calcium disodium EDTA and malic acid are instructed to take these products without meals.

... take a quality oral chelation product containing calcium disodium EDTA on an empty stomach and also take a quality multivitamin/multimineral supplement with meals.




Product: *ToxDetox - Glutathione & EDTA synergy. INDEX
https://oradix.com/edta-line/
8-toxdetox-glutathione-edta-synergy-with-a-free-stopreabsorb-bowel-cleanse.html
LINK 2: http://www.toxdetox.com/
2017-09-04--- US$149.00 Special--- US$179.00 Regular --- Savings -US$30.00
2017-09-04--- Ca$203.00 Special--- Ca$2??.00 Regular --- Savings -Ca$4?.00
Availability date: 10/01/2015

Glutathione (600mg) and Ca-EDTA (1,600mg), one month supply, comes with a FREE 'StopReabsorb' bowel cleanse.
Beats Detoxamin(R) and other similar EDTA products.

Over 3X more toxins are excreted.
The free StopReabsorb bowelcleanse cuts down on the reabsorbtion of toxins from the colon.

ToxDetox™ is a nutritional industry first - with never before available, professional strength reduced Glutathione (600mg) and CaNa2EDTA (1,600mg) in a cocoa butter based rectal suppository. As ToxDetox™ was researched and developed, a human study concurrently confirmed the powerful benefits of combined Glutathione and EDTA application for toxic removal:
3.8 times more toxins were excreted in the urine compared to EDTA only or Glutathione only applications.
ToxDetox beats Detoxamin(R) and other similar EDTA products.

ToxDetox™ raises the bar among detoxification products for efficiency, safety, and a broader spectrum of toxins removed, along with Glutathione’s immune boosting properties.

ToxDetox™ successfully targets the main health impacts of environmental and endogenous toxins:
mitochondrial toxicity, immunotoxicity, endocrine and neurotoxicity.

Suppositories provide very similar results to IV methods of administration since the ingredients in the suppository are absorbed by the wall of the rectum and carried straight into the systemic circulation (circumventing the entero-hepatic portal system where ingredients are broken down). Rectal absorption could be also compared to transdermal (through the skin) absorption due to the anatomy of the rectum.

De-calcification (EDTA) and immune boosting (glutathione) should be always a part of the best detoxification protocols.

CaNa2EDTA has been safely and widely used, since the 1950s, to bind and remove toxic heavy metal contamination in the body.

Lead, mercury, cadmium, manganese, iron, aluminum, arsenic, uranium, and other metals replace calcium, kept in the ring-shaped CaNa2EDTA, as it is being excreted.

Dosage
The recommended therapy is a minimum of three boxes of ToxDetox™.
Take and extra box for every ten years over the age of 40 (4 boxes over 50, 5 boxes over 60, etc.)
The total number of suppositories required depends on your toxicity level and exposure to toxic metals.

    It is recommended to take a ToxDetox™ suppository every forth nights over the first two weeks for a slower start and every second days afterwards at bedtime, after a bowel movement, or as recommended by your health care professional.

    Take your StopReabsorb bowel cleanse oral capsules 2 hours before you go to bed in the evenings, whenever you take a ToxDetox suppository.


There are benefits in going through with the whole detox program again a year later.
By this time the toxins from the deeper storage locations (e.g. from the bones) have time to come to more superficial places for effective detoxification.

Use one suppository weekly for maintenance.

    How to Use ToxDetox™

  • consider taking StopReabsorb™ bowel cleanse capsules 2 hours
    before taking the suppository to stop the reabsorption of toxins from the colon

  • take your daily vitamins as usual

  • take your minerals at least 5 hours BEFORE taking the suppository (to avoid mineral-toxin competition)

  • it is recommended to eat your dinner and drink a glass of water 2 to 3 hours before your bedtime

  • empty your bowels before inserting the suppository


    • remove the plastic wrapping from one suppository

    • moisten the suppository or put a bit of coconut oil to the tip of the suppository for easier insertion

    • insert it gently into the rectum past the sphincter muscles with your finger (use a “sandwich bag” for cleaner insertion)

    • try not to empty your bowels overnight (or for a few hours)


  • keep yourself hydrated while detoxifying

  • preferably eat organic, non-GMO, and 50% raw food

  • try to reduce/avoid EMF (Electro Magnetic Field) radiation to increase the rate of metal excretion from your body(!)

  • do daily high intensity, intermittent bouts of exercises to improve blood and lymph circulation (and spike your HGH levels). Ideally, these high-intensity interval trainings consist a total of 10 minutes of very intense exertion (swimming,sprinting, jumping) with short recovery periods in between. Combine this with 'SuperSlow weight lifting'

  • reduce your calorie intake or fast a day or two per week to open up your fat cells to release more (fat soluble) toxins

Our current diet and lifestyle conditions do not support high enough levels of glutathione and thus it must be supplemented.

Glutathione is the most important, natural, master detoxifier and the body's main antioxidant, protecting our cells and making our energy metabolism run well. Normally glutathione is recycled in the body -- except when the toxic load becomes too great.

Glutathione levels are significantly lower in chronic disease patients, suggesting either that glutathione deficiency contributes to the disease, or, more likely, that chronic diseases use high levels of protective glutathione. In either case, supplementation with glutathione could be expected to alleviate much of the cellular toxicity that contributes to diseases, which is why animal and human studies suggest an important role for glutathione supplementation in chronic disease conditions.

CAUTION:
ToxDetox™ should not be used during breastfeeding or pregnancy, as the toxins would then be passed on to the baby.
However, it is strongly recommended to detoxify months before conception for healthier, less toxic babies. Keep out of reach of children. Store at either room temperature or refrigerate. Never freeze.

Reference:
[1] Effect of glutathione on the cadmium chelation of EDTA in a patient with cadmium intoxication.
Gil HW et al. Hum Exp Toxicol. 2011 Jan;30(1):79-83. Epub 2010 Apr 22.

EDTA has both strong 'antibiotic' effects on its own and through its profound bacterial biofilm disrupting effects. These dual actions can turn MultiDrug-Resistant (MDR) microorganisms into resistant ones (!), underlining the lifesaving role EDTA can play. In a study, EDTA treatment of Pseudomonas aeruginosa biofilms resulted in 1,000 fold greater killing than treatment with the antibiotic gentamicin

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Product: KelaminHM 1500, Chelation Health Products. INDEX
http://chelationhealthproducts.com/chelation/
Chelation Health Products: 866.573.9687
833 West 500 North, Salt Lake City, UT, 84116
LINK 2: Chelation Club membership request.
LINK 3: KelaminHM 1500, suppositories --- 30 + 10 FREE! (per box)
Regular: USA $169.00

EDTA chelation therapy is the primary method for ridding the body of heavy metal toxicity, including the presence of lead, cadmium, aluminum, mercury, arsenic, and even iron. At this time, chelation is also effectively treating occlusive vascular diseases in conjunction with diet, nutritional supplements, and lifestyle changes. Because EDTA chelation appears to improve circulation and reduce toxic chemical reactions in the body, it has also been used successfully for arthritis, diabetes, high blood pressure, and eye diseases such as macular degeneration.

KelaminHM EDTA Chelation suppositories effectively remove the widest range of toxic heavy metals including Mercury, Lead, Aluminum and Copper. KelaminHM is a suppository that consists of Calcium Disodium EDTA in a Cocoa Butter base.

EDTA, the active ingredient, is a synthetic amino acid that needs to remain whole to be effective.
When used orally about 95% of the EDTA will be destroyed by the acids in the stomach before it can be utilized making this route very ineffective. Getting EDTA via I.V., while effective, is very time consuming, expensive and potentially dangerous due to the high dosage. With a suppository there is about 95% Absorption rate and no requirement for blood work to determine sufficient kidney and liver function as is required before getting I.V. EDTA treatments.

After you insert the suppository into the rectum it melts through body heat and is then absorbed through the colon wall directly into the blood stream via the hemmorhoidal veins. The middle and lower hemorrhoidal veins bypass the liver and kidneys on the first pass, allowing the EDTA to remain in the body for up to 8 hours, 4 times longer than EDTA from an I.V. The circulatory and lymphatic systems are very large so the more time you give the EDTA to bind with toxic heavy metals the more effective it will be.

The Endothelium is a single cell layer thick membrane that lines the Circulatory and Lymphatic Systems.
This membrane has several functions which include: production of Nitric Oxide which helps the circulatory system dilate and relax, summoning of White Blood Cells, and assisting in the regulation of coagulation of the blood. The primary cause of Endothelial Dysfunction is the buildup of toxic heavy metals which prevents the Endothelium from performing its functions effectively.

Nitric Oxide is a gas produced in the Endothelium which controls the relaxing or dilation of the blood vessels.
If Nitric Oxide is not produced the blood vessels will become rigid causing hardening of the arteries. The EDTA in KelaminHM will remove toxic heavy metals from the Endothelium helping it to function efficiently thereby increasing blood flow.

The EDTA in KelaminHM will bind with some essential minerals but at a much slower rate than toxic heavy metals.
Your body will breakdown and utilize essential minerals such as Iron, Zinc, Calcium and Magnesium but not toxic heavy metals as it does not have any use for them. The toxic heavy metals will settle into the lining of your circulatory and lymphatic systems, soft tissue and organs.

Since the EDTA can only bind with what it finds we do not feel that it will deplete your body of essential minerals as long as you eat a balanced diet and supplement on a regular basis. We recommend taking your Mineral supplements about 8 hours post or prior to using KelaminHM to give your body enough time to break down and utilize the essential minerals it needs before the EDTA has a chance to bind with them.

KelaminHM is made with the same ingredients as both Kelatox and Detoxamin.
The only difference is that KelaminHM offers stronger dosages than Detoxamin and is sold for a much lower price than either Kelatox or Detoxamin.

Shipping is FREE to international and Canadian customers.
Shipping within the United States is free as long as the order subtotal is equal to or greater than $100.00.




Product: Protect EDTA, Nutristand. INDEX
https://www.nutristand.com/chelation-protection-products/
LINK 2: https://nutristand.com/product/protect-edta/
Regular: USA $39.95 --- 120 vegetarian capsules
Save 25% on all items, 33% on 3 of any item, and 50% on a purchase of 6 or more or with an Auto Order.

Protect EDTA reduces heavy metals stored throughout the body.
Heavy metals interfere with many biochemical reactions. Reducing these contaminants can support the normal structure and function of the cardiovascular system.

... components of healthy food can help protect us from this modern day environment.
Malic acid as found in fruits and berries and the cysteine found in garlic are two such items that can help eliminate and detoxify harmful chemicals.

Four vegetarian capsules provide the following amounts:

Ingredients: 
1,200 mg Malic Acid
1,000 mg EDTA Quadruple Mineral Chelate
   200 mg Cysteine (as L-Cysteine and N-Acetyl-L-Cysteine) 
   200 mg Garlic (Allium sativum) bulb powder, deodorized
   100 mg Parsley (Petroselinum sativum) leaf powder 

2015: We have replaced half of the garlic extract with two forms of an amino acid found in garlic, cysteine and n-acetyl cysteine. This provides an enhanced function over garlic alone. The Protect EDTA has 10% of the EDTA as the magnesium dipotassium form to provide a better spectrum of minerals that release during the chelation process.

2015: Protect EDTA contains a blend of approximately 90% calcium disodium EDTA with 10% magnesium dipotassium EDTA. The calcium disodium EDTA has the longest history of safe use (since the 1960’s). As these minerals get released during the chelation process, magnesium and potassium are better cardiovascular focused minerals and serve to balance the calcium and sodium.




Product: Oral Drops, INDEX
https://www.evenbetterhealth.com/heavy-metal-poisoning-treatment.php

EDTA is a chelating agent that can bind free metal ions that circulate in the blood stream.
Traditional EDTA treatment for chelation has involved giving it to patients intraveneously. However, more recently, there has been a German-patented formula that utilizes a very dilute amount of EDTA so that low side effects are experienced and it can be used at home without doctor's supervision. The active ingredients in this formula set up shop in the gastrointestinal tract where through the Law of Isotonicity, metal ions are dumped into the bloodstream (over time) and then excreted safely out of the body through the urine and stool.




Product: EDTA, Natural, Arizona Natural Products. INDEX
https://www.amazon.ca/Natural-EDTA-600-100-Capsules/dp/B00014IA0C/
ref=sr_1_1?ie=UTF8&qid=1511932545&sr=8-1&keywords=Natural+EDTA
Retail: C $23.75 -- Special: C $18.96 -- You Save: CDN$ 4.79 (20%)
Date first available at Amazon.ca: Aug. 27 2013
Item model number: 1210

Arizona Natural Products, Calcium Disodium EDTA Description: Calcium Disodium EDTA Chelating Agent

EDTA Calcium Disodium EDTA is a pharmaceutical grade chelating agent designed to bind and render inactive certain trace metals. This product is intended to supplement intravenous chelation therapy of plaque and other mineral deposits throughout the cardiovascular system.

Since EDTA may deplete levels of important vitamins and minerals, supplementing your diet with a daily multi-vitamin is recommended.

Other Ingredients: Calcium disodium EDTA, rice flour, magnesium stearate.Each capsule contains 600 mg. Calcium Disodium EDTA.




LINKS from Lenntech, and others. INDEX
http://www.lenntech.com/

LINK 2: http://rmalab.com/sites/default/files/tests/instructions/20140107_CI_UrineElement.pdf
Rocky Mountain Labs Clinical Info report for Professionals, 2014-01-07
An assessment of the benefits and limitations of various test protocols.

Lenntech Phone: +31 152 610 900 --- Lenntech e-mail: info@lenntech.com


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I gathered and researched this data, mediated with the Grace of God through prayer, first, as a benefit in my interest in exploring available digital information which would acquaint me with the overall content related to the subject. I have found that God is ALWAYS available when we are Reverent in our Asking, open-minded in our Listening, and, Assertive in our Choice of Action. Doctors did not expect me to survive birth. In the past 25 years, medical and health "experts" have cautioned or directed me, more than 14 times, that I had little time left to live, or would die ... because THEY did not understand my challenges, were not motivated to professionally diagnose, or, chose to superstitiously recall as absolute previously flawed training. I am still alive beyond age 70. With the assistance of God, my Personality, the research and lack of dismissiveness of a number of persons ... I have found resolution to numerous health challenges. This has enabled me to assist many others who had been abandoned. May it also empower you. This is one document which you may find helpful as a BASIC introduction to the subject.