Enhancer

Dimercaptosuccinic acid (DMSA)
Succimer, Chemet

Chelating Agent, esp Lead, Mercury.

Revised 2018-03


      Top INDEX
    • Basics: Enhancement.
    • About : Dimercaptosuccinic acid, Wikipedia.
    • About : DMSA, nd Health Facts.
    • Details: Dr. Clifford Koganow's Summary.
    • Details: DMSA Drug Information.
    • Caution: Common & Rare Side Effects.

    • Product: DMSA Synergy, GS Nutrients.
    • Product: DMSA 100mg, Living Supplements.
    • Product: DMSA, Meso 2,3 dimercaptosuccinic acid.
    • Article : (DMSA), ...Treatment For Heavy Metal Toxicity.
    • Protocol : A suggested application.
    • Technical: The Andy Cutler Protocol.

      Product Possibilities, NOT Recommendations.
    • Product: DMSA Synergy, GS Nutrients.
    • Product: DMSA, Living Supplements, 100 mg, SA
    • Product: DMSA (Meso 2,3 dimercaptosuccinic acid).
    • Product: DMSA Synergy, xx mg
    • Product: Heavy Metal Blockade, DMSA
    • Product: DMSA, Living Supplements, 20-25-50-100 mg

    • Technical: The Andy Cutler Protocol.
    • Research: Other LINKS.
    • Insight: Combination Therapy.
    • Insight: Dental sourced mercury.
    • Insight: Lead poisoning factors.

    • -LINKS: from Lenntech, and others.
    • -Focus-: Monographs on Toxins and Enhancers.

Enhancement is a Potential, not a Guarantee.
With awareness, patience, and choice we can optimize.
Water and air are fundamental to our form of life.
Too much of either leads to death; air = embolism; water = drowning.
Too little of either leads to death; air = suffocation; water = dehydration.
The healthy Balance for each of us is dynamic and personal.




Basics: Enhancement. INDEX
http://warddeanmd.com/dmsa-and-detoxing-heavy-metals/
LINK 2: https://www.drmyattswellnessclub.com/DMSA.htm
LINK 3: http://www.advance-health.com/chelation.html

The objective of oral chelation is to improve ones health and nutritional status by replacing toxic heavy metals with essential elements.

One concern with chelation therapy in general is that chelating agents are not as specific as we would like and are likely to remove essential trace minerals as well as toxic metals. Trace mineral replacement therapy is essential when doing any form of chelation. Trace mineral therapy is important on its own as well since the essential minerals compete with toxic metals for binding sites. In other words, when ones body is properly mineralized, the absorption and toxicity of heavy metals is greatly reduced. It is my view that the majority of us are malnourished in terms of minerals and trace minerals.

... chelation agents include EDTA, Vitamin C (Ascorbic Acid), methionine, cysteine, malic acid, DMSA (dimercapto succinic acid) and Garlic. In addition, toxic heavy metals can to some degree be displaced by the essential minerals and trace minerals. This is particularly interesting in the case of iodine when used in high doses (Iodoral).

DMSA treatment results in the greatest urinary excretion of mercury, compared to other heavy metal chelators, as well as being the most effective at removing mercury from the blood, liver, brain, spleen, lungs, large intestine, skeletal muscle and bone. Mercury excretion is greatest in the first eight to 24 hours after ingestion. ...

DMSA is very safe, and usually causes few side effects.
Some patients may experience slight gastrointestinal distress or itching, when higher doses are used.

As with any chelating agent, DMSA can cause deficiencies of copper, manganese, molybdenum and zinc, if they are not replaced by supplementation. DMSA doesn’t directly bind magnesium, cysteine, or glutathione, but heavy metal detoxification can result in depletion of these nutrients as well.

(in the USA) The FDA has ruled that it cannot be sold - it seems that there is a prescription drug available that contains the exact same ingredients, so the FDA must "protect" us from the non-prescription supplement form of DMSA.




About: Dimercaptosuccinic acid, Wikipedia. INDEX
https://en.wikipedia.org/wiki/Dimercaptosuccinic_acid

Dimercaptosuccinic acid (DMSA), also called succimer, is a medication used to treat lead, mercury, and arsenic poisoning. When radiolabeled with technetium-99m, it is used in a number of types of diagnostic testing.
It is taken by mouth for 19 days.
More than two weeks should pass before a second course is given.

    Common side effects include
    • vomiting,
    • diarrhea,
    • rash,
    • low blood neutrophil levels ....
    • Liver problems and
    • allergic reactions

It is unclear if use during pregnancy is safe for the baby.
Dimercaptosuccinic acid is in the chelating agent family of medications.
It works by binding with lead and a number of other heavy metals allowing them to leave the body in the urine.

Dimercaptosuccinic acid has been used medically since the 1950s.
It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. In the United States there was no generic version available as of 2015.
A course of treatment costs more than US $200 (about $6.63 per 100 mg pill).
In India, it costs about $1.24 per 100 mg pill.

Its elimination half-life is 2.5–3.5 hours.
DMSA can cross the blood–brain barrier of mice,[10] but not that of humans, limiting its use to extracting heavy metals from parts of the body other than the central nervous system.

DMSA facilitates urinary excretion of lead, and with sufficiently aggressive treatment, can reduce lead content in the brain.

DMSA also increases urinary excretion of copper and zinc.
DMSA improved cognitive function in rats that had been exposed to lead, but reduced cognitive function in rats that had not been exposed to lead.

The relative activities of a series of novel monoalkyl esters of meso-2,3-dimercaptosuccinic acid (MiADMSA) have been examined as agents for the mobilization of cadmium, lead and arsenic owing to the ability of these monoesters to cross cell membranes. The monoesters were found to be more effective than the parent compound DMSA. The complexes (monoesters of DMSA) seem to penetrate cells (not possible in the case of DMSA), which helps in targeting intracellular sites in the body and aids in the removal of toxic metal ions in the cytosol and organelles inside the cell.

DMSA was first synthesized by V. Nirenburg in the Urals Polytechnic Institute, commissioned by one of the electrical enterprises of Sverdlovsk, which consumed many tons of mercury and was looking for a medicine to prevent poisoning of personnel.

In 1957, it was found by Chinese scientists that DMSA can effectively treat antimony poisoning due to overdose of tartar emetic.

Pronounced protective effect in animal poisoning with arsenic and mercury was first shown by I. Okonishnikova in 1962. In 1984 the now-defunct Bock Pharmaceutical Company requested the FDA grant approval for Orphan drug status under the trade name Chemet and the FDA approved of this in 1991 providing exclusivity until 1998 which was conveyed to the successor Sanofi in 1996.




About: DMSA, nd Health Facts. INDEX
http://www.ndhealthfacts.org/wiki/DMSA
17 March 2014

DMSA is the common name for dimercaptosuccinic acid, also known as dimethylsuccinic acid, or disodium monomethanearsonate. It is commonly used in chelation therapy with individuals that have elevated levels of mercury or lead.

DMSA was initially studied in China, Japan, and Russia in the 1950s for treating heavy metal toxicity, and in the 1970s gained popularity in Europe and the USA.

DMSA is commonly used in individuals with elevated levels of either mercury or lead as an alternative to BAL or D-penicillamine as it has a significantly better side effect profile.

DMSA has a relatively short half life, about 60 minutes, and concentrates predominately in extracellular fluid. Although its pharmacodynamics are not completely understood, its suggested that the majority of its chelating action occurs through the kidney.

Heavy Metal Toxicity
DMSA is used to treat elevated lead and mercury levels.
It can also be useful in chelating antimony, cadmium, and arsenic.

Autism
DMSA has been shown to improve behavioural symptoms in autism spectrum disorder.

Diagnostics
DMSA is commonly used in provocative urinary analysis testing.
Urine is tested pre and post administration of DMSA to identify total body burden of heavy metals

Safety
Kidney and Liver Function
Caution should be shown with use in patients with impaired liver or kidney function.[6]

Side Effects

    • GI symptoms,
    • rash,
    • headaches,
    • dizziness, and increased liver function tests.
    • DMSA contains sulhydryl compounds with will make urine smell sulfourous

Efficacy

Lead
DMSA is effective in increasing urinary excretion of lead, and decreasing blood levels of lead.

Mercury
When compared to DMPS, and D-penicillamine, DMSA has been shown to more effectively remove mercury from the blood, liver, brain, spleen, lungs, muscle, and bone. DMSA was less effective than DMPS at removing mercury from the kidneys.

Other Heavy Metals
Clinical studies have demonstrated that DMSA is safe and effective in decreasing total body burden of mercury, arsenic, and cadmium.




Details: Dr. Clifford Koganow's Summary. INDEX

Dimercaptosuccinic acid (DMSA) is a drug (CHEMET) approved for use in the treatment of lead poisoning.
It is a chelating agent that binds to heavy metals such as lead and mercury, which are then eliminated in the urine as the DMSA is excreted. A significant benefit is that it does not remove substantial amounts of other beneficial metals such as iron, calcium, magnesium and zinc.

In addition to the therapeutic use of DMSA, a brief administration of DMSA followed by measurement of heavy metals in the urine is used as an indicator of the body burden of heavy metals. The greater the body burden of toxic metals, the greater the amount excreted after DMSA.

The approach to this test is that any increase in heavy metals after DMSA challenge is considered significant.
The patient is then treated with DMSA treatment until the toxic metals in the urine are within the normal range after a DMSA challenge.

An additional complication for children is that even a six-hour urine collection may be difficult.
Therefore, a single urine sample collection after DMSA may sometimes be used.




Details: DMSA Drug Information. INDEX
https://www.drugs.com/mmx/dmsa.html

Generic Name: Succimer
Commonly used brand name(s): Chemet
Other commonly used names are dimercaptosuccinic acid.

Toxicity, lead (treatment)
Succimer is indicated for the treatment of lead poisoning in children with blood lead concentrations above 45 mcg per deciliter.
[Succimer also is indicated to treat lead toxicity in adults.]

Use of succimer should be accompanied by identification and removal of the source of lead exposure.

    Signs and symptoms of severe, symptomatic lead poisoning
    • anemia,
    • gastrointestinal complaints (abdominal pain and vomiting),
    • nephropathy, and
    • encephalopathy.

The combination of dimercaprol and edetate calcium disodium is considered to be the treatment of choice for lead encephalopathy.

Orally active succimer is a heavy metal chelating agent that forms stable, water-soluble complexes with lead and consequently increases the urinary excretion of lead.

The site of lead chelation by succimer is not known.




Caution: Common & Rare Side Effects. INDEX
https://www.webmd.com/drugs/2/
drug-78431/dmsa-bulk/details/list-sideeffects
for DMSA (Bulk) 98 % Powder.
LINK 2: http://www.ndhealthfacts.org/wiki/DMSA
LINK 3: https://www.evenbetterhealth.com/heavy-metal-poisoning-treatment.php

DMSA may deplete zinc and copper.

Common side effects of DMSA (Bulk) 98 % powder:

    • Diarrhea, Less Severe
    • Irritation Of The Stomach Or Intestines, Less Severe
    • Loss Of Appetite, Less Severe
    • Throwing Up, Less Severe

Infrequent side effects of DMSA (Bulk) 98 % powder:

    • Decreased Neutrophils A Type Of White Blood Cell, Severe
    • Rash, Less Severe

Rare side effects of DMSA (Bulk) 98 % powder:

    • Hypersensitivity Drug Reaction, Severe
    • Abnormal Liver Function Tests, Less Severe
    • Anemia, Less Severe
    • Not Feeling Well, Less Severe

A Caveat for all Chemical Chelator Usage.

hese most commonly known chelators need to be taken in fairly high doses to be truly effective.
Because of this, side effects are virtually unavoidable. Accordingly, these potent pharmaceuticals cannot be taken for an extended period of time (Goodman & Gilman).

As well, because of the high doses needed with these chelators, essential minerals are almost always chelated out of the body as well. Minerals most commonly lost include zinc, magnesium, manganese, molybdenum, and selenium, which then need to be replaced.

Toxic metals are often stored in the brain, and none of the above-mentioned chelators cross the blood/brain barrier.

And last but not least, there has been concern that the metals loosened by the chelating agents are not always properly excreted. Instead, they may be reabsorbed in different parts of the body, causing more damage to the immune system and vital organs. This is why some individuals can remain just as sick after chelation as before, sometimes for years after their "detoxing".




Article : (DMSA), ...Treatment For Heavy Metal Toxicity. INDEX
http://www.altmedrev.com/publications/3/3/199.pdf
Alternative Medicine Review, Volume 3, Number 3, 1998
(Altern Med Rev 1998;3(3):199-207)
by Alan L. Miller, N.D.
Correspondence address: P.O. Box 25, Dover, ID 83825. alan@thorne.com

... It has long been acknowledged that sulfhydryl-containing compounds have the ability to chelate metals.
The sulfur-containing amino acids

      methionine and cysteine, cysteine’s acetylated analogue N-acetylcysteine, the methionine metabolite S-adenosylmethionine, alpha-lipoic acid, and the tri-peptide glutathione (GSH)
    all contribute to the chelation and excretion of metals from the human body.

Meso-2,3-dimercaptosuccinic acid (DMSA), is a water-soluble, sulfhydryl-containing compound which is an effective oral chelator of heavy metals. Initial studies over 40 years ago identified DMSA as an effective antidote to heavy metal poisoning. DMSA was subsequently studied for 20 years in the People’s Republic of China, Japan, and Russia before scientists in Europe and the United States “discovered” the substance and its potential usefulness in the mid-1970s.

DMSA is a dithiol (containing two sulfhydryl, or S-H, groups) and an analogue of dimercaprol (BAL, British Anti-Lewisite), a lipid-soluble compound also used for metal chelation. DMSA’s water solubility and oral dosing create a distinct advantage over BAL, which has a small therapeutic index and must be administered in an oil solution via painful, deep intramuscular injection.

DMSA, on the other hand, has a large therapeutic window and is the least toxic of the dithiol compounds.

LEAD

Lead competes in the body with calcium, causing numerous malfunctions in calcium-facilitated cellular metabolism and calcium uptake and usage, including inhibition of neurotransmitter release and blockade of calcium channels and calcium-sodium ATP pumps.

The central nervous system (CNS) appears to be affected the greatest by lead.
Children in particular are susceptible to its devastating effects on mental development and intelligence.
Neurobehavioral deficits resembling attention deficit disorder have also been found in lead-exposed children.

Blood lead concentrations of 20-25µ g/100 ml can cause irreversible CNS damage in children.

Poor quality nutrition, including deficiencies in iron and calcium, are known to exacerbate the manifestations of lead exposure, including its CNS effects.

Acute adult lead exposure leads to

renal proximal tubular damage;

chronic exposure causes renal dysfunction characterized by

    • hypertension,
    • hyperuricemia,
    • gout, and
    • chronic renal failure.

Inorganic lead is absorbed, distributed, and excreted.
Once in the blood, lead is distributed primarily among three compartments – blood, soft tissue (kidney, bone marrow, liver, and brain), and mineralizing tissue (bones and teeth). Mineralizing tissue contains about 95 percent of the total body burden of lead in adults. After lead is absorbed in the human body, it reacts with thiol (sulfhydryl) groups on peptides and proteins, inhibiting enzymes involved in heme synthesis and interfering with normal neurotransmitter functions.

This natural reaction with thiols is also the body’s method of eliminating lead, especially from the liver.
Hepatic glutathione attaches to lead and enhances its excretion in the feces.
Unfortunately, hepatic glutathione can be depleted in this manner, resulting in less glutathione being available for conjugation of other toxic substances. In addition to these hepatic effects, individuals with higher concentrations of blood lead have been noted to have lower levels of erythrocyte reduced glutathione.

Decreased erythrocyte glutathione is due to the fact that 99 percent of lead in the blood is attached to red blood cells; the remaining one percent is in the plasma. Lead stored in bone has a half-life of 25 years, although lead in bone can be mobilized into the blood, and subsequently to other tissues, ... After lead is absorbed in the human body, it reacts with thiol (sulfhydryl) groups on peptides and proteins, inhibiting enzymes involved in heme synthesis and interfering with normal neurotransmitter functions. Poor quality nutrition, including deficiencies in iron and calcium, are known to exacerbate the manifestations of lead exposure, including its CNS effects.

Acute adult lead exposure leads to renal proximal tubular damage; chronic exposure causes renal dysfunction characterized by

    • hypertension,
    • hyperuricemia,
    • gout, and
    • chronic renal failure.

MERCURY
Humans are exposed to mercury primarily in two forms: mercury vapor and methyl mercury compounds.
Unfortunately, mercury is a ubiquitous substance in our environment. Mercury vapor in the atmosphere makes its way into fresh and salt water by falling in precipitation. Methyl mercury compounds are created by bacterial conversion of inorganic mercury in water and soil, which subsequently concentrates in seafood and fish. Dietary fish intake has been found to have a direct correlation with methyl mercury levels in blood and hair.

“Silver” amalgam dental fillings are the major source of inorganic mercury exposure in humans.
This term, however, is a misnomer, as this compound is not predominately silver; the proper term should be “mercury amalgam.” The most common dental filling material, amalgams contain approximately 50 percent liquid metallic mercury, 35 percent silver, 9 percent tin, 6 percent copper, and a trace of zinc. As they are prepared and placed in the patient’s mouth, the dentist and the person preparing the amalgam, as well as the patient are exposed to mercury vapor (HgO) up to a 15.6-fold increase in mercury in expired air after chewing.

Mercury release was found to be greater in corroded amalgams compared to new, polished fillings.

Mercury vapor from amalgams enters the bloodstream after being inhaled into the lungs.
** Comparisons of blood levels of mercury and the number of amalgams show a direct correlation between number of amalgam fillings and concentration of blood and urine mercury.

In addition, a statistically significant correlation was found between the number of dental amalgam fillings and mercury content of the kidney cortex (p less than 0.0001) and the occipital lobe cortex of the brain (p less than 0.0016) in cadavers.

After removal of all amalgams, there is a transient increase in mercury concentration in the blood, plasma, and feces, followed by a decrease in blood levels below the preremoval baseline.

Mercury vapor is lipid soluble, freely passing through cell membranes and across the blood-brain barrier.
Methyl mercury also easily crosses the blood-brain barrier and the placenta.

Inorganic and methyl mercury have a high affinity for sulfhydryls, reacting intracellularly with the sulfhydryl group on glutathione and cysteine, and histidine residues in proteins, and allowing transport out of the cell. In rats, it was found that mercury secretion into the bile was dependent on glutathione secretion into the bile, suggesting the biliary secretion of mercury is in large part dependent on the biliary transport of GSH.

In humans, 90 percent of mercury elimination is via the feces, with only 10 percent normally being excreted in the urine.

A decrease in hepatic glutathione content secondary to excretion of mercury can decrease hepatic cell viability by mechanisms stated earlier.

ARSENIC and Cadmium.
Environmental arsenic and cadmium exposure comes from pollutants discharged from industries utilizing these metals, including herbicide and battery manufacturers. These metals are also found in cigarette smoke. Cadmium, as well as lead and mercury, can interact metabolically with nutritionally essential metals. Cadmium interacts with calcium in the skeletal system to produce osteodystrophies, and competes with zinc for binding sites on metallothionein, which is important in the storage and transport of zinc during development. Biliary excretion seems to be an essential factor for the fecal elimination of cadmium and arsenic, although these metals may be also excreted in the urine.

Pharmacokinetics of DMSA
In healthy individuals, approximately 20 percent of an oral dose of DMSA is absorbed from the gastrointestinal tract.
95% of the DMSA that makes it to the bloodstream is bound to albumin. Most likely, one of the sulfhydryls in DMSA binds to a cysteine residue on albumin, leaving the other S-H available to chelate metals. In healthy fasting men, 90 percent of the DMSA recovered in the urine was found to be mixed disulfides of DMSA (DMSA attached to one or two cysteine molecules), and 10 percent was free unchanged DMSA. No mixed disulfides werefound in the blood.

It is thought these are formed as albumin releases DMSA in the kidney.

DMSA Treatment in Lead Toxicity
DMSA has been used since the 1950s as an antidote for lead poisoning in Russia, Japan, and the Peoples Republic of China. DMSA has been shown in recent studies to be a safe and effective chelator of lead, reducing blood levels significantly.

At a dose of 10 mg/kg for five days in adult males, DMSA lowered blood lead levels 35.5 percent; a more aggressive approach utilizing a 30 mg/kg dose lowered blood lead 72.5 percent. Clinical symptoms and biochemical indices of lead toxicity also improved.

An animal study indicated DMSA is an effective chelator of lead in soft tissue, but it may not chelate lead from bone.

Another found DMSA or calcium disodium ethylenediamine tetraacetic acid (CaNa EDTA) produced significant reductions in kidney, bone and brain lead levels, but DMSA produced greater reductions of bone lead.

Combination Therapy: INDEX
In a preliminary animal study, combination therapy with DMSA and CaNa EDTA was more effective than either individual chelator at increasing urinary and fecal elimination of lead, and reducing hepatic, renal, and femur lead concentrations in rats.

It has been suggested that chelating agents, including BAL and CaNa EDTA, may mobilize and redistribute lead to soft tissue, including the brain. Lead-exposed rats given CaNa EDTA showed an initial decrease in bone and kidney lead, and an increase in hepatic and brain lead concentrations, indicating redistribution to these organs.

Rats administered DMSA in combination with CaNa EDTA showed increased urinary lead output and decreased tissue burden versus use of these therapeutic substances individually. No redistribution of lead to the brain was observed with the combined therapy. A decrease in blood zinc level was noted with the combination, as has been observed with CaNa

EDTA monotherapy.
In a study of lead’s pro-oxidant activity and the effect of thiol substances as antioxidants, 5 weeks of lead exposure in mice depleted hepatic and brain glutathione (GS) levels, and increased malondialdehyde (MDA), a marker of lipid peroxidation. DMSA administration for 7 days resulted in a reduction in blood, liver, and brain lead levels. N-acetylcysteine supplementation decreased MDA levels, indicating amelioration of oxidative stress by NAC, but it did not decrease lead levels.

In an animal study, co-administration of ascorbic acid (vitamin C) with DMSA enhanced the urinary excretion of lead in rats compared to DMSA alone.

DMSA Treatment in Mercury Toxicity
DMSA has been in recent use as a treatment for mercury poisoning since Friedheim reported on DMSA treatment of experimental toxicity in mice in 1975, noting its low toxicity and favorable efficacy compared to BAL and D-penicillamine.

Since that time, numerous animal and human studies have shown DMSA administration increases urinary mercury excretion and reduces blood and tissue mercury concentration.

In a comparison study of chelating agents, 11 construction workers with acute mercury poisoning were treated with either DMSA or N-acetyl-D,L-penicillamine (NAP), another sulfhydryl-containing metal chelator. DMSA treatment resulted in greater urinary excretion of mercury than NAP.

In a study of single-dose, DMSA-induced urinary excretion in occupationally-poisoned workers, a significant increase in urinary mercury excretion was noted, especially in the first 24 hours. Mercury excretion was greatest in the first eight hours after oral DMSA administration.

After methylmercuric chloride administration in rats, DMSA, DMPS, and NAP were studied for their ability to remove mercury from blood and tissue. DMSA was the most effective at removing mercury from the blood, liver, brain, spleen, lungs, large intestine, skeletal muscle, and bone. DMPS was more effective at removing mercury from the kidneys.

Chelation of Mercury from the Brain
In rats, following intravenous administration of methyl mercury, DMSA was found to be the “most efficient chelator for brain mercury.”

In another animal study, DMSA was given four days after methyl mercury injection in mice, and continued for eight days. DMSA removed two-thirds of the brain mercury deposits, NAP removed approximately one-half, while DMPS did not remove significant amounts of mercury from the brain.

DMSA has also been used effectively in arsenic and cadmium poisoning.

Mercury Diagnostic and Treatment Protocol
Hair analysis is an inexpensive and valuable tool for evaluating prior mercury exposure.

An effective way to evaluate mercury toxicity quantitatively is to determine the amount of mercury excreted in the urine after a challenge dose of DMSA. A baseline 24-hour urine is collected before the challenge, then again on day three of a three-day dosing of 200 mg three times a day. The therapeutic dosage of DMSA for mercury toxicity is not well defined in the literature. Doses as high as 30 mg/kg per day have been used, with no serious side effects noted.

... More studies need to be done to define optimal dosing strategies ...

Be aware that sulfhydryl compounds in DMSA will make urine smell very sulfurous.
Adequate communication with the patient regarding this issue is important, so they are not taken by surprise. Adjunctive nutrient therapy includes hydrolyzed whey protein, as it contains cysteine and cysteine residues which can be of benefit while using DMSA.

Cysteine is the rate-limiting step in glutathione production, necessary for fecal heavy metal excretion and hepatoprotection. Whey also contains branched-chain amino acids, which will occupy transport sites at the blood-brain barrier, effectively keeping bound metals from being re-deposited in the brain.
Supplemental dosing of N-acetylcysteine (NAC), 500 mg three times per day, can also be helpful.




Protocol : A suggested application. INDEX
http://www.dmsachelation.com/protocol/

How Much DMSA Do I Take?
How much DMSA you take is based solely on body weight.
Dosage is given in ranges so you can start at a lower level and work your way up to the higher level once your body gets used to DMSA The exact formula and recommendations is provided when you order DMSA.

DMSA Protocol.

Dosage
Dosage is based on body weight as follows. In this case the patient is a 70 pound child.
Adults use the same formula to figure out dosage requirements, simply substitute your weight. ...

20-30 mg of DMSA per kilogram of body weight per day – (to a maximum of 2 gms per day)
(if you prefer to calculate in pounds, its approximately 9-13 mg of DMSA per pound of body weight per day)

1 kilogram equals 2.2 pounds therefore to figure this out in pounds do the following:

Divide your childs weight in pounds by 2.2
example: a 70 pound child weights approximately 32 kilograms and would require 640 to 960 mgs of DMSA per day,
this is 6 to 9 capsules for one day.

Monthly Treatment Protocol
Hopefully you have established the correct dosage your child needs.
This dosage is only taken for 3 DAYS.
Then one day of rest (nothing taken).
Followed by 9 days of supplement replacement (high quality multivitamin such as Greens Plus)
then another day of rest (nothing taken).

Now repeat this procedure. Below is a monthly summary.

Monthly Summary (days 1 to 30)


Days 1-3
Take DMSA, 1/3 of the total daily dosage taken 3 times during the course of the day.
example: your child weights 70 pounds therefore his/her total daily dosage is 640-960 mgs.

Why the range?
Each individual tolerates the DMSA differently, use the lower range of 640 mg if child develops symptoms, use the high range of 960 mg if child has no symptoms. For first time use the low range is suggested until it is determined how well the childs body tolerates DMSA.

How To Give DMSA
It may be difficult to get an autistic child to swallow a capsule.
It is therefore recommend that the total daily dose be combined in a favourite beverage
(do not put in milk products or grapefruit juice) and

1/3 of this drink be given to the child in the morning, 
another 1/3 at lunch, and 
the final 1/3 at dinner or in the evening. 

For this example, a 70 pound child, simply pull apart the 7 of the 100 mg capsules and mix them into the drink.
Then pour 1/3 of this drink into a separate cup and give it to the child in the morning.
Give the next 1/3 at lunch time and
the final 1/3 at dinner or in the evening.

Ideally, DMSA should be given every 4 hours as it has a 4 hour half-life inside the body.
Practically, however, it is not always feasible to get yourself and your child up throughout the night to do this.
If you choose to follow the 3 days on 11 days off schedule, getting up in the night may be workable as you only have to do it for 3 days.

Other chelation schedules, such as 7 days on, 7 days off, are not suited for this.

Day 4
Rest. Child does NOT take any DMSA.

Days 5-13
Child does NOT take any DMSA.
Child follows supplement replacement therapy as determined by yourself or your health care practioner.
A high quality multi-vitamin is recommended. A high quality diet is critical for autistic children, this cannot be overstated.


A few tips.

Completely avoid ‘man-made’ products such as artificial sweeteners (aspartame, sorbitol, splenda etc) and the processed food found at typical fast food places, and microwave dinners etc. Simple whole foods are best and will help your child get better sooner.

STRONGLY suggest that your autistic child eat real butter as is contains arachidonic acid and linoleic acid, both of which are necessary for vital brain function. The addition of real butter into a childs diet has been shown to greatly help children with attention deficit disorders. Avoid all butter substitutes such as margarine. If you can afford organic butter (approx $8 per pound) it’s even better.

Avoid ‘bad’ fats such as vegetable oil, corn oil, canola oil and ALL products that contain these oils.
Read labels on food. Become a smart consumer. Instead use olive oil, coconut oil, and hemp seed oil (very close to the perfect ration of 4:1 omega 6 to omega 3).

Avoid sugar (read labels), this includes things that are converted into sugar such as grains (white bread), white pasta, corn syrup (read labels, its in almost everything).


These are basic diet tips, become an expert on nutrition and learn to heal your child.
Email for more basic, cheap, and easy diet tips.

Day 14
Rest. Child does NOT take any DMSA.

Day 15
Start taking DMSA again. Repeat days 1-15.

Summary
This completes the one month treatment protocol.
Follow this protocol for 3 month then do the 24 hour urine challenge (Email for details about how to do this and cost) to measure the levels of heavy metals, specifically mercury still remaining in your child.

Note: DMSA cannot cross the blood brain barrier by itself.
It needs to be combined with alpha-lipoic acid (very inexpensive at any pharmacy or walmart, walgreens etc) to do this.
When all the mercury has been removed from the childs body THEN you can start removing it from the brain.
This is the final stage.
Do not add alpha-lipoic acid at the start of the DMSA treatment.


Overview of Mercury and Lead Poisoning
Our bodies are constantly exposed to an onslaught of environmental toxins.
Lead and mercury are two heavy metals that seem to have found their way into almost everyone.
Lead and mercury do not occur naturally in the body and as such are very toxic.

These two heavy metals are known to interfere with how nerves communicate.
Meso-2,3-dimercaptosuccinic acid (DMSA) is a compound approved in the 1960’s by the FDA for the removal (chelation) of heavy metals. DMSA is considered the preferred agent for the chelation (removal) of heavy metals in both adults and children. Mercury is considered to be the second most toxin substance on the planet (uranium is #1) and the negative effects of lead exposure are well documented.

Meso-2,3-dimercaptosuccinic acid (DMSA) is also known as succimer and sold as a prescription under the trade name Chemet, note that Chemet contains sucralose, a know neuro-toxin, probably not something you want to give to your child. DMSA is also sold as an over the counter nutritional supplement in some areas.

DMSA has a somewhat strong sulfur like smell. It’s chemical properties make it particularly suited to chelate (remove via excretion) mercury and lead, the two most common toxic heavy metals in people. DMSA isn’t particular about what heavy metals it removes, it simply grabs all the metals it encounters. When you are chelating mercury you are also removing over 15 other heavy metals.

How Did I Get Heavy Metals (Mercury and Lead) In My Body?
There are several possible ways heavy metals got into your body.
Below each of the more common exposures will be discussed.
Remember there are no safe levels for heavy metals.

Chelation of toxic heavy metals with DMSA is well documented in the scientific literature.
There are several other chelation agents but DMSA so far as been proven to be the safest and most effective.

Mercury

There are 4 main sources of mercury poisoning:

1. In Vitro, passed from mother to baby

2. Vaccinations

3. Dental Amalgams or ‘Silver Fillings’

4. Contraception Pills and Contact Lense Solution


1. In Vitro
A mother with mercury in her body will pass it into her baby.
The level of mercury in the tissue of the fetus, newborn, and young children is directly proportional to the number of silver fillings in the mother’s mouth.

2. Vaccinations
Vaccinations are the #1 mercury exposure in infants, and the #2 exposure in adults.

    25% of vaccines today still contain mercury.
    Flu shots still contain mercury.
    When mercury is removed from flu shots, it is replaced with other heavy metals such as aluminum and formaldehyde.

Mercury is used as a preservative in vaccinations.
Vaccinations are currently a hot topic of debate with some parents linking autism to vaccinations.
Flu shots contain mercury also, as a preservative.

According to the EPA the average child can tolerate 0.3 micrograms of mercury.
Note that a 2 month old infant receiving all 4 scheduled vaccinations (DtaP, Polio, Hib, Hepatitus B) will have a mercury level of 62.5 micrograms, 125 times higher than the EPA ‘safe’ level.

3. Dental Amalgams or ‘Silver Fillings’
Amalgam fillings leech methyl-mercury into your body.
Methyl-mercury is particularly dangerous as its attracted to tissues and organs and can actually cross the blood brain barrier and get into your brain.

Fact: Most major countries other than the U.S. have extensive bans and health warnings regarding the use of amalgam fillings. This includes Austria, Australia, Canada, France, Great Britain, Japan, New Zealand, Norway, Sweden, and Switzerland.

Fact: In 1988 scrap dental amalgam material was declared a hazardous waste by the EPA (Environmental Protection Agency). OSHA has certain mandates present to handle amalgam fillings before going into and out of your mouth. The OSHA guidlines include:

    Scrap amalgam must be stored in an unbreakable, tight sealed container away from heat.
    Use a ‘no-touch’ technique for handling the amalgam
    Store under liquid, preferably glycerin or photographic fixer solution

What about fish?
There is inorganic mercury in fish but the amount that actually ends up in the human body from fish consumption is very low and has been blown out of proportion by the media.

4. Contraception Pills and Contact Lense Solution
Mercury used to be used in both of these products.
It has since been discontinued. Using these products in the 1980’s would have exposed you to mercury, which in turn would be passed from mother to child.



Lead
Lead is one of the most prominent metals you will see on any tests.
Our parents were part of the lead generation, it takes 4 generations to eliminate their exposures.
Sources include leaded paint, leaded gasoline, painted dishes, toys from China, candy from Mexico, children’s jewelry, and canned foods to name just a few. The point is if its in your body you need to get it out. DMSA is able to effectively chelate lead from the human body.

Lead is particularly toxic to children, leading to Attention Deficit Disorder (ADD) and Hyperactive Disorders.
Their growing nervous system is negatively impacted by chronic and acute lead exposure.
DMSA has been shown to be safe for use in children.

The 24 hour urine challenge should be done before and after a DMSA chelation program.
During the Urine Challenge, DMSA is used as the provoking agent to measure the level of lead in the body.

DMSA Chelation
The chemical process behind how DMSA works to chelate heavy metals from the body is somewhat technical and beyond the scope of this article. The basic mechanism is that DMSA has receptor sites that the heavy metals bind to. New research suggests the following action. Heavy metals reside inside the cells of the body and DMSA cannot enter the cells.

Instead glutathione (the body’s natural chelator) residing inside the cell pushes the metals out of the cell whereby they are picked up by DMSA and excreted. Now you might say can’t I just take a glutathione supplement and force more heavy metals out of the cell? The answer is no because naturally occurring glutathione levels are 100 higher inside the cell than outside. Any glutathione supplement you take will end up circulation around the outside of the cell only. What you need to do instead is take the precursor for glutathione so you body will manufacture its own glutathione. One known pre-cursor (the chemical that allows your body to make its own glutathione) is N-AcetylCysteine, abbreviated as NAC. Glycine also plays a large role in the production of glutathione, which is why its in the DMSA Synergy product.

DMSA should be taken in on again and off again cycles.
Ideally 3 days on and 11 days off.
The reason is that the body needs 11 days to regenerate its glutathione levels.
Three days on and 11 days off is the fastest and safest way to use DMSA to chelate heavy metals.

DMSA and the Blood Brain Barrier
As previously stated DMSA can NOT cross the blood brain barrier.
One study exists with lab rats wherein the DMSA did cross the blood brain barrier. However these test animals were so toxic that their normal functioning was greatly impaired. The results have never been duplicated so its safe to say that DMSA cannot cross the blood brain barrier. DMSA must be taken in conjunction with alpha-lipoic acid to cross the blood brain barrier. After you have chelated the heavy metals from your body (know as ‘lowering your body burden’) you should then add alpha-lipoic acid with your DMSA to pull the mercury and other metals from your brain.

DMSA is taken in capsule form.
Other competing forms of chelation, namely ETDA (suppositories) and DMPS (intraveniously) are more dangerous and less effective. DMSA is thought to remove small amounts of beneficial minerals, therefore a vitamin and mineral supplement such as a high quality multi vitamin should be taken in conjunction with DMSA

What To Expect
Initially you may feel slightly tired when taking DMSA.
However, once the metals start leaving your body you will experience a sense of well-being and increased energy and focus.
Your ability to concentrate will increase greatly.
The so-called ‘brain fog’ will be gone.
Your memory will improve, these are just a few of the benefits of chelating with DMSA.

Where To Buy DMSA
Prescription DMSA costs approximately $2-$3 per capsule and many over the counter manufacturers have stopped supplying DMSA completely as the US government is trying to make DMSA prescription only. This will put it out of the reach of many people. DMSA is available for as little as $0.60 per capsule.



Technical: The Andy Cutler Protocol.
DMSA, a chelator.
INDEX
http://www.livingnetwork.co.za/chelationnetwork/chelation-the-andy-cutler-protocol/

DMSA – you can start this four days after mercury amalgam removal.
DMSA chelates specifically lead and mercury.

It is a man-made substance and was introduced initially to chelate lead for children.

DMSA doesn’t cross the blood brain barrier to any clinical degree and only chelates extracellular mercury.
DMSA has a half-life of four hours.
DMSA is used early in treatment to lower the blood/body levels before adding ALA, due to ALA’s ability to go into and out of the brain. For this reason ALA should NOT be added too early.

Many need to start with very small dosages of DMSA for long periods to test tolerance and reduce the body burden before increasing the dosage or using ALA (this can be done for as long as a year for some mercury-toxic people that cannot tolerate ALA early, or at all). It is generally recommended to do several rounds (at least three or four) on DMSA at low dosages before changing dosage or adding ALA. Each component is changed separately so you know which (dose or substance) is causing resultant side-effects/problems. If you use both chelators simultaneously and have problems you won’t know which one is causing them.

DMSA is not a sulphur-based drug.
The molecule is based on succinic acid.
DMSA is a synthetic (man-made) compound, while ALA is a naturally occurring compound.
Both release and bind toxins which means you should make certain you are taking sufficient antioxidants to support the detoxification process. Consult a medical practitioner aware of the Cutler approach if possible.

DMSA has the effect of reducing the side effects when used in conjunction with ALA, especially for those with a supposed lower body burden and higher brain burden. DMSA can help reduce symptoms after recent amalgam removal.

DMSA, or any chelator, can exacerbate existing symptoms, so it is advised that oral chelation is begun with low doses and close attention paid to symptoms. Start with doses of 12.5 mg and increase slowly over a number of rounds.

Some people believe they have an allergy to the DMSA compound itself, but it is actually the incorrect dosage or timing of dose that is causing problems. If you are having side-effects with 12.5 mg you can lower the dose further to 5 mg. It is of course possible, that you cannot tolerate DMSA no matter what the dose.

DMSA is excreted through the kidneys which means this pathway of elimination must be flowing well.




Product: DMSA Synergy, GS Nutrients. INDEX
https://www.dmsachelation.com/product/90-capsules-of-dmsa-synergy/
90 Capsules of DMSA each containing 100 mg of pure DMSA.
Regular: USA $89.97 --- Special: $ ---

Want to order by phone? --- Call 1-347-535-4322 --- (10 am – 5 pm New York Time Zone)

All other forms of payment accepted including bank drafts, wires, and personal checks.
Contact us if you would to use these one of these payment methods.

> Each Capsule Contains:

100 mg pure DMSA
    200 mg Ascorbic Acid (Vitamin C)
    50 mg Glycine

Why The Other Ingredients?
Ascorbic Acid and Glycine have been proven to significantly increase the effectiveness of DMSA.

DMSA Synergy is more effective than DMSA alone.

A Note About Expiry Dates
All our DMSA is very fresh, a minimum of more than 1 year away from expiring.
Because new stock is always arriving it would be difficult to constantly update these pages with actual expiry dates.
Our DMSA comes directly from the manufacturer, it never sits on a warehouse shelf where it could get stale and lose some of its effectiveness like some other DMSA products.




Product: DMSA 100 mg, Living Supplements. INDEX
https://www.livingsupplements.com/index.php?main_page=product_info&products_id=189 Regular: $28.88 for 50 capsules.

> Ingredients: capsules, each containing:

    • DMSA (Dimercapto Succinic Acid) 100mg
    • Vitamin C (as ascorbic acid, derived from a non-GMO corn source) 50 mg (% daily value 83%)
    • with Vegetable cellulose capsules & microcrystalline cellulose, and nothing else added.
    • Manufactured in a GMP-certified facility using USP-grade raw materials only.

All goods are dispatched within 2 working days.
---- Shipping Weight: 0.08kgs
---- 250 Units in Stock
---- Manufactured by: Living Supplements




Product: Meso 2,3 dimercaptosuccinic acid (DMSA). INDEX
http://suissepharma.com/products.html
LINK 2: http://www.suissepharma.com/mobile/products.html
Featured Product: DMSA
120 Capsules, 125 mg - USA $58.00

DMSA is a water-soluble compound containing sulfhydryl that binds to soft heavy metals such as lead and mercury, mobilizing the ions for excretion. Initial studies over 50 years ago identified DMSA as an effective antidote to heavy metal poisoning.

Please visit www.SuissePharma.com for a no-cost online consultation to determine medical tests and healthcare practitioners you may want to review.

SUISSE PHARMA trademark by Life Sciences Group in Claymont, DE, 19703
Berufsverband der Schweizer Apotheker. Berne, Switzerland

Swiss Pharma Ltd.
100 King St. West, Toronto, ON M5X1C9
416-857-6090

The correspondent listed for SUISSE PHARMA is

SUSAN M. DIXON
PO BOX 7237,
WILMINGTON, DE USA
19803-0237




Product: DMSA Synergy, xx mg INDEX
http://dmsasynergy.com/dmsasynergy320.html
220 Capsules -- (vegetarian) -- USA $200.00
Vitamin C mg, DMSA 25 mg, Glycine mg

Email: sales@dmsasynergy.com
6629857 Canada Inc
3210 Rue Felix-Leclerc
# 32443, Vaudreuil-Dorion, 
Quebec J7V8W0
Canada

DMSA was approved by the FDA in 1992 for the detoxing and chelation (removal) of heavy metals, specifically, Mercury and Lead in both children and adults.

In use since the 1950s, no other substance has been found to be more practical, more safe, and more effective for this purpose.

Some people believe that DMSA allows autisitc children to behave better, listen, and focus more, because it removes mercury and other heavy metals from their body.

This product is manufactured in Canada to exacting standards in an FDA approved facility.

NOTE: NO PRESCRIPTION NECESSARY
This is an over the counter supplement but it should be used under the direction of a health care professional or someone familiar with this supplement. If you do not have access to such a person we can assist you free of charge.

Email and phone support is also available free of charge.

If you prefer to pay another way, please contact us and we will accomodate you.
We accept, checks, money orders, bank drafts, wire transfers, etc.
We will find a way to accept your preferred payment method.
If you are paying by check/cheque or money order, please make it payable to 6629857 Canada Inc.
All prices listed as USD.

We will ship DMSA to any country.




Product: Heavy Metal Blockade, DMSA INDEX
http://www.nationalnutrition.ca/detail.aspx?ID=5224 750MG - 120 VCAPS
Manufactured By: New Roots
Code: NR0639
Reg: $41.04 -- Sale: $36.93 -- (Savings: $4.11) Nov 24, 2017

New Roots Herbal’s Heavy Metal Blockade is to be used in the heavy metal elimination program in conjuction with DMSA, Heavy Metal Blockade contains N-acetylcysteine, which, when taken in doses of 500 mg three times per day, can be very helpful for the elimination of heavy metals from your body, as it reduces malondialdehyde (MDA), a marker of lipid peroxidation.

Ingredients:

500 mg   N-Acetyl Cysteine    
200 mg   Vitaminc C (Ascorbic Acid) 
 50 mg   Alpha Lipoic Acid  

Take 1 to 3 capsules daily before meals on an empty stomach, for 40 days.
Take 3 capsules daily when taking DMSA for mercury, lead and other heavy metal detoxification, or as directed by your Health care practitioner.

HEAVY METAL DETOXIFICATION
Often overlooked, Mercury toxicity can play a large role in the development of common disorders.
Sub-clinical mercury toxicity occurs when there is enough mercury in the body to aggravate a number of symptoms or other disorders, but not identifiably high enough to meet the clinical definition of toxicity by this heavy metal.

Complicating matters further for the treatment of moderate mercury toxicity is that different people will generally tolerate different levels of mercury in their bodies. Common health concerns aggravated by even moderate levels of mercury include:

    • candida,
    • allergies,
    • MS,
    • Lupus,
    • adrenal stress,
    • depression,
    • anxiety,
    • fatigue,
    • leaky gut and
    • others.




Product: DMSA, Living Supplements, SA INDEX
https://www.livingsupplements.com/
Strengths available in 1mg to 100 mg

14 Pinetree Crescent, Vredehoek, 
Cape Town, 8001, South Africa

  1. DMSA 20 mg WITHOUT Vit C
    USA $23.52 -- 90 capsules
    Ingredients
    DMSA (Dimercapto Succinic Acid) 20mg
    with Vegetable cellulose capsules, microcrystalline cellulose and nothing else added.
    Manufactured in a GMP-certified facility using USP-grade raw materials only.
    NB. Please keep your products tightly closed, as they contain an oxygen absorber to keep them from oxidizing.
    This product was added to our catalog on Thursday 20 August, 2015.

  2. DMSA 25 mg
    $25.36 -- 90 capsules
    Ingredients
    DMSA (Dimercapto Succinic Acid) 25mg
    Vitamin C (as ascorbic acid, derived from a non-GMO corn source) 50mg (% daily value 83%)
    with Vegetable cellulose capsules & microcrystalline cellulose, and nothing else added.
    Manufactured in a GMP-certified facility using highest-grade raw materials only.
    NB. Please keep your products tightly closed, as they contain an oxygen absorber to keep them from oxidizing.
    This product was added to our catalog on Friday 09 September, 2011.

  3. DMSA 50 mg
    $29.77 -- 90 capsules
    Ingredients
    DMSA (Dimercapto Succinic Acid) 50mg;
    Vitamin C (as ascorbic acid, derived from a non-GMO corn source) 50mg (% daily value 83%)
    with Vegetable cellulose capsules & microcrystalline cellulose, and nothing else added.
    Manufactured in a GMP-certified facility using highest grade raw materials only. NB. Please keep your products tightly closed, as they contain an oxygen absorber to keep them from oxidizing.
    This product was added to our catalog on Sunday 31 October, 2010.

  4. DMSA 100 mg
    $29.40 -- 50 capsules
    Ingredients
    DMSA (Dimercapto Succinic Acid) 100mg
    Vitamin C (as ascorbic acid, derived from a non-GMO corn source) 50mg (% daily value 83%)
    with Vegetable cellulose capsules & microcrystalline cellulose, and nothing else added.
    Manufactured in a GMP-certified facility using USP-grade raw materials only.
    NB. Please keep your products tightly closed, as they contain an oxygen absorber to keep them from oxidizing.
    This product was added to our catalog on Tuesday 21 June, 2016.


Additional Information:

Time zone : GMT +2 hours Contact Form: ... page=contact_us
To avoid spam, we have excluded our email address from being viewed here,
and instead request that you make use of the contact form...
Please bear in mind the time zone differences whilst awaiting a reply
i.e. we generally won't be able to respond between 10pm and 8am GMT +2 hours.

Parcels ship at 10.00am GMT, on the nearest Monday, Wednesday or Fridays.
Orders placed on Friday after 10am GMT, will only ship on Monday.

International parcels are first couriered to the UK, where they are re-shipped globally ....

Both Registered and non-registered options are sent via the same International First Class Air Mail and have the same time-frames.

Shipping Time: Maximum 5 weeks, if not received, contact them.
CANADA: Ave. 3-5 weeks, (sometimes 6 weeks as spend long periods in Canada customs)
No tracking options

Canada (max 3 of same product at one time)





Technical: The Andy Cutler Protocol.
DMSA, a chelator.
INDEX
http://www.livingnetwork.co.za/chelationnetwork/chelation-the-andy-cutler-protocol/

DMSA – you can start this four days after mercury amalgam removal.
DMSA chelates specifically lead and mercury.

It is a man-made substance and was introduced initially to chelate lead for children.

DMSA doesn’t cross the blood brain barrier to any clinical degree and only chelates extracellular mercury.
DMSA has a half-life of four hours.
DMSA is used early in treatment to lower the blood/body levels before adding ALA, due to ALA’s ability to go into and out of the brain. For this reason ALA should NOT be added too early.

Many need to start with very small dosages of DMSA for long periods to test tolerance and reduce the body burden before increasing the dosage or using ALA (this can be done for as long as a year for some mercury-toxic people that cannot tolerate ALA early, or at all). It is generally recommended to do several rounds (at least three or four) on DMSA at low dosages before changing dosage or adding ALA. Each component is changed separately so you know which (dose or substance) is causing resultant side-effects/problems. If you use both chelators simultaneously and have problems you won’t know which one is causing them.

DMSA is not a sulphur-based drug.
The molecule is based on succinic acid.
DMSA is a synthetic (man-made) compound, while ALA is a naturally occurring compound.
Both release and bind toxins which means you should make certain you are taking sufficient antioxidants to support the detoxification process. Consult a medical practitioner aware of the Cutler approach if possible.

DMSA has the effect of reducing the side effects when used in conjunction with ALA, especially for those with a supposed lower body burden and higher brain burden. DMSA can help reduce symptoms after recent amalgam removal.

DMSA, or any chelator, can exacerbate existing symptoms, so it is advised that oral chelation is begun with low doses and close attention paid to symptoms. Start with doses of 12.5 mg and increase slowly over a number of rounds.

Some people believe they have an allergy to the DMSA compound itself, but it is actually the incorrect dosage or timing of dose that is causing problems. If you are having side-effects with 12.5 mg you can lower the dose further to 5 mg. It is of course possible, that you cannot tolerate DMSA no matter what the dose.

DMSA is excreted through the kidneys which means this pathway of elimination must be flowing well.




LINK: http://www.newdayhealthproducts.com

LINK: http://www.healthmasters.com

LINK: http://www.vivagen.net/detoxprods.htm

LINK: http://www.seeknatural.co.uk/product-1136.html

LINK: http://www.supersmart.com

LINK: http://dmsachelation.com/




LINKS from Lenntech, and others. INDEX
http://www.lenntech.com/

LINK 2: http://rmalab.com/sites/default/files/tests/instructions/20140107_CI_UrineElement.pdf
Rocky Mountain Labs Clinical Info report for Professionals, 2014-01-07
An assessment of the benefits and limitations of various test protocols.

Phone: +31 152 610 900 --- info@lenntech.com


LINK to
INDEX page
(offline)
LINK to Empower,
Maintain, & Repair
YOUR Health


INDEX


Articles on the Internet are transitory.
The publishers may remove them, change sites, change URLs, or change titles.
For the purpose of maintaining an availability of these articles for us, I have reprinted parts here with authorship maintained, coding simplified for error-free loading and minimal file size, and a LINK to the original document. NOTHING in writing is absolute; don't treat human opinion, projection, and observation as an Idol. Doing so can kill you, or worse, have you impose abuse on others.

I gathered and researched this data, mediated with the Grace of God through prayer, first, as a benefit in my interest in exploring available digital information which would acquaint me with the overall content related to the subject. I have found that God is ALWAYS available when we are Reverent in our Asking, open-minded in our Listening, and, Assertive in our Choice of Action. Doctors did not expect me to survive birth. In the past 25 years, medical and health "experts" have cautioned or directed me, more than 14 times, that I had little time left to live, or would die ... because THEY did not understand my challenges, were not motivated to professionally diagnose, or, chose to superstitiously recall as absolute previously flawed training. I am still alive beyond age 70. With the assistance of God, my Personality, the research and lack of dismissiveness of a number of persons ... I have found resolution to numerous health challenges. This has enabled me to assist many others who had been abandoned. May it also empower you. This is one document which you may find helpful as a BASIC introduction to the subject.